Mutant protein

A mutant protein is the protein product encoded by a gene with mutation.[1] Mutated protein can have single amino acid change (minor, but still in many cases significant change leading to disease) or wide-range amino acid changes by e.g. truncation of C-terminus after introducing premature stop codon.

See also
  • Site-directed mutagenesis
  • Phi value analysis
  • missense mutation
  • nonsense mutation
  • point mutation
  • frameshift mutation
  • silent mutation
  • single-nucleotide polymorphism

References
  1. Wang, Qing; Chaerkady, Raghothama; Wu, Jian; Hwang, Hee Jung; Papadopoulos, Nick; Kopelovich, Levy; Maitra, Anirban; Matthaei, Hanno; et al. (2011). "Mutant proteins as cancer-specific biomarkers". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2444–9. Bibcode:2011PNAS..108.2444W. doi:10.1073/pnas.1019203108. PMC 3038743. PMID 21248225.


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