Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[5][6] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[5] or T3 receptor-associating cofactor 1 (TRAC-1).[6]

NCOR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
External IDsOMIM: 600848 MGI: 1337080 HomoloGene: 31370 GeneCards: NCOR2
Orthologs
SpeciesHumanMouse
Entrez

9612

20602

Ensembl

ENSG00000196498

ENSMUSG00000029478

UniProt

Q9Y618

Q9WU42

RefSeq (mRNA)

NM_006312
NM_001077261
NM_001206654

NM_001253904
NM_001253905
NM_011424

RefSeq (protein)

NP_001070729
NP_001193583
NP_006303
NP_001193583.1

NP_001240833
NP_001240834
NP_035554

Location (UCSC)Chr 12: 124.32 – 124.57 MbChr 5: 125.02 – 125.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[5] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[7]

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[8]

Discovery

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[5] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[6]

Interactions

Nuclear receptor co-repressor 2 has been shown to interact with:

References
  1. GRCh38: Ensembl release 89: ENSG00000196498 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029478 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. Sande S, Privalsky ML (July 1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Molecular Endocrinology. 10 (7): 813–25. doi:10.1210/mend.10.7.8813722. PMID 8813722.
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  8. UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
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Further reading
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