Nanoimpellers

Nanoimpellers are an experimental technology developed to eliminate some of the harmful effects of chemotherapy by facilitating treatment of only specific areas of the body. Nanoimpellers are nanoscale, light-activated containers filled with cancer-fighting drugs that only release their contents when hit by a specific type of laser.[1]

Nanoimpellers for cancer drug delivery were first demonstrated in 2008.[2][3] Initial work used ultraviolet light, however the low penetration in tissue and potential for toxicity mean this is not well suited for delivery in patients.[1] Later work has shifted to using near infrared light and two photon excitation (TPE) to trigger release.[4][5]

See also
  • Nanochemistry
  • Two-photon excitation microscopy

References
  1. Zheng, Yue Bing; Kiraly, Brian; Huang, Tony Jun (November 2010). "Molecular machines drive smart drug delivery". Nanomedicine. 5 (9): 1309–1312. doi:10.2217/nnm.10.111. PMID 21128714.
  2. Lu, Jie; Choi, Eunshil; Tamanoi, Fuyuhiko; Zink, Jeffrey I. (31 March 2008). "Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells". Small. 4 (4): 421–426. doi:10.1002/smll.200700903. PMC 2712492. PMID 18383576.
  3. "Nanomachine Kills Cancer Cells With Exposure To Light". Inventorspot. 25 April 2008. Retrieved 30 March 2015.
  4. Tian, He; Zhang, Junji (2016-06-14). Photochromic Materials: Preparation, Properties and Applications. John Wiley & Sons. p. 223. ISBN 9783527683703.
  5. Croissant, Jonas; Maynadier, Marie; Gallud, Audrey; Peindy N'Dongo, Harmel; Nyalosaso, Jeff L.; Derrien, Gaëlle; Charnay, Clarence; Durand, Jean-Olivier; Raehm, Laurence; Serein-Spirau, Françoise; Cheminet, Nathalie; Jarrosson, Thibaut; Mongin, Olivier; Blanchard-Desce, Mireille; Gary-Bobo, Magali; Garcia, Marcel; Lu, Jie; Tamanoi, Fuyuhiko; Tarn, Derrick; Guardado-Alvarez, Tania M.; Zink, Jeffrey I. (16 December 2013). "Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers". Angewandte Chemie International Edition. 52 (51): 13813–13817. doi:10.1002/anie.201308647. PMC 3940420. PMID 24214916.


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