Ohmecarfentanil

Ohmecarfentanil (RTI-4614-38), also known as Ohlofentanil, is a mu opioid receptor agonist from the class of fentanyl analogues which was found to be 30,000 times more potent than morphine in the rhesus monkey single dose suppression test.[1] This makes ohmecarfentanil, along with some closely related analogues, among the most potent opioid agonists known at this time, even surpassing lofentanil and ohmefentanyl.

Ohmecarfentanil
Legal status
Legal status
Identifiers
IUPAC name
  • Methyl 1-(2-hydroxy-2-phenylethyl)-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H32N2O4
Molar mass424.541 g·mol−1
3D model (JSmol)
SMILES
  • 3R,4R: CCC(=O)N(C1=CC=CC=C1)[C@@]2(CCN(C[C@H]2C)CC(C3=CC=CC=C3)O)C(=O)OC

  • 3R,4S: CCC(=O)N(C1=CC=CC=C1)[C@]2(CCN(C[C@H]2C)CC(C3=CC=CC=C3)O)C(=O)OC
InChI
  • 3R,4R: InChI=1S/C25H32N2O4/c1-4-23(29)27(21-13-9-6-10-14-21)25(24(30)31-3)15-16-26(17-19(25)2)18-22(28)20-11-7-5-8-12-20/h5-14,19,22,28H,4,15-18H2,1-3H3/t19-,22?,25-/m1/s1
  • Key:HVTQDIBOZUDMTH-PJHDFATGSA-N

  • 3R,4S: InChI=1S/C25H32N2O4/c1-4-23(29)27(21-13-9-6-10-14-21)25(24(30)31-3)15-16-26(17-19(25)2)18-22(28)20-11-7-5-8-12-20/h5-14,19,22,28H,4,15-18H2,1-3H3/t19-,22?,25+/m1/s1
  • Key:HVTQDIBOZUDMTH-CGPDNSSVSA-N

See also

References
  1. Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (April 2021). "Designer drugs: a medicinal chemistry perspective (II)". Annals of the New York Academy of Sciences. 1489 (1): 48–77. doi:10.1111/nyas.14349. PMID 32396701. S2CID 218617085.


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