Open Insulin Project

The Open Insulin Project is a collection of researchers and advocates working to develop an open source protocol for producing insulin that is affordable, has transparent pricing, and is community-owned.[1][2][3][4]

Formation2015
FounderAnthony Di Franco
HeadquartersCounter Culture Labs
Location
  • Bay Area, California, USA
Websiteopeninsulin.org

History

The Open Insulin Project was started in 2015 by Anthony Di Franco, himself a type 1 diabetic.[5] He started the project in response to the unreasonably high prices of insulin in the US. The project has been housed in Counter Culture Labs, a community laboratory and maker space in the Bay Area.[6] Other collaborators include ReaGent, BioCurious and BioFoundry.

Goals

The project aims to develop both the methodology and hardware to allow communities and individuals to produce medical-grade insulin for the treatment of diabetes.[7] These methods will be low-cost in order to combat the high price of insulin in places like the US. There is also potential for small-scale distributed production that may allow for improved insulin access in places with poor availability infrastructure. Access to insulin remains so insufficient around the globe that "Half of all people who need insulin lack the financial or logistical means to obtain adequate supplies".[8]

Motivation

Researcher Frederick Banting famously[9] refused to put his name on the patent after discovering insulin in 1923. The original patent for insulin was later sold by his collaborators for just $1 to the University of Toronto in an effort to make it as available as possible.[10] Despite this, for various reasons,[11] there remains no generic version of insulin available in the US. Insulin remains controlled by a small number of large pharmaceutical companies and sold at prices unaffordable to many who rely on it to live, particularly those without insurance. This lack of availability has led to fatalities, such as Alec Smith, who died in 2017 due to lack of insulin.[12] The Open Insulin Project is motivated by the urgent need to protect the health of those with diabetes regardless of their economic or employment status by developing low-cost methods for insulin production available for anyone to use.

Progress and status

The project has made significant progress via genetically engineered yeast, and according to their December 2018 release the "first major milestone ― the production of insulin at lab scale ― is almost complete".[13]

The cost to produce insulin via Open Insulin methods is estimated by the project to be such that "roughly $10,000 should be enough to get a group started with the equipment needed to produce enough insulin for 10,000 people".[1]

A more recent estimate by the Open Insulin Foundation states that it will cost $200,000 (one-time price, per patient of $7-$20) for used equipment and up to $1,000,000 (one-time price, per patient of $73) for new equipment.[14]

See also
  • OpenAPS, a project to create open source artificial pancreas system technology
  • Nightscout

References
  1. Burningham, Grant (October 24, 2019). "The Price of Insulin Has Soared. These Biohackers Have a Plan to Fix It". Time. Archived from the original on 2020-09-09. Retrieved 2019-12-14.
  2. Black, Erin (2019-01-26). "Insulin has become so expensive that this diabetic is trying to make his own". CNBC. Retrieved 2020-08-16.
  3. Smith, Dana G. (2019-05-30). "Biohackers With Diabetes Are Making Their Own Insulin". Medium. Retrieved 2020-08-16.
  4. Ossola, Alexandra (November 18, 2015). "These Biohackers Are Creating Open-Source Insulin". Popular Science. Retrieved 2019-12-14.{{cite web}}: CS1 maint: url-status (link)
  5. Tucker, Miriam E. (15 July 2015). "Biohackers Aim To Make Homebrew Insulin, But Don't Try It Yet". NPR. Retrieved 2020-08-16.
  6. "Counter Culture Labs, cradle of Bay Area biohacking". Makery. Retrieved 2020-08-16.
  7. "About the project". Open Insulin Project. Retrieved 2020-08-16.
  8. Decoder, News. "Insulin access a challenge for governments, diabetics - News Decoder". news-decoder.com. Retrieved 2020-08-16. {{cite web}}: |first= has generic name (help)CS1 maint: url-status (link)
  9. Hegele, Robert A. (1 May 2017). "Insulin affordability". The Lancet Diabetes & Endocrinology. 5 (5): 324. doi:10.1016/S2213-8587(17)30115-8. PMID 28434485.
  10. "The History of a Wonderful Thing We Call Insulin | ADA".
  11. Belluz, Julia (2019-04-03). "The absurdly high cost of insulin, explained". Vox. Retrieved 2020-08-16.
  12. "Insulin's High Cost Leads To Lethal Rationing". NPR.org. Retrieved 2020-08-16.
  13. "New Frontiers for the New Year". Open Insulin Project. 2018-12-31. Archived from the original on 2019-02-01. Retrieved 2020-10-27.
  14. Lassalle, Louise (17 February 2020). "How much will it cost to install and run a small scale insulin production system?". Open Insulin Foundation. Archived from the original on 2020-11-23. Retrieved 2021-03-16.
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