Organ dysfunction

Organ dysfunction is a condition where an organ does not perform its expected function. Organ failure is organ dysfunction to such a degree that normal homeostasis cannot be maintained without external clinical intervention.

It is not a diagnosis. It can be classified by the cause, but when the cause is not known, it can also be classified by whether the onset is chronic or acute.

Multiple organ failure can be associated with sepsis and is often fatal. Countries such as Spain, have shown a rise in mortality risk, due to a large elderly population there.[1]

However, there are tools physicians use when diagnosing multiple organ failure and when prognosing the outcome. The Sequential Organ Failure Assessment (SOFA) score[2] uses early lab values in a patient's hospitalization (within 24 hours) to predict fatal outcomes for a patient. There’s no single answer to what causes organ failure, and depending on the patient, there can be many factors involved. Another tool that can become available to individuals experiencing Organ Dysfunction is Organ Donation. The end goal is to help stop the organ failure process and reverse effects when possible through a transplant. [3]

References

  1. Bouza C, López-Cuadrado T, Saz-Parkinson Z, Blanco J (2014). "Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011)". BMC Infect Dis. 14 (1): 717. doi:10.1186/s12879-014-0717-7. PMC 4327809. PMID 25528662.
  2. Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL (2001). "Serial evaluation of the SOFA score to predict outcome in critically ill patients". JAMA. 286 (14): 1754–8. doi:10.1001/jama.286.14.1754. PMID 11594901.
  3. "Multiple Organ System Failure (MOSF) | Kindred Hospitals". Kindred. Retrieved 2022-10-20.


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