Peak-to-trough ratio

Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C_max (peak) concentration and C_min (trough) concentration over a dosing interval for a given drug.[1][2] A drug with an elimination half-life of 24 hours taken once per day will have a peak-to-trough ratio of approximately 2.[1] Peak-to-trough ratio is proportional to half-life and to dosing interval, with longer half-lives and shorter dosing intervals giving smaller ratios.[3]

Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C_max) and trough (C_min) levels of a drug over its dosing interval (τ) at steady state.

References

Dennis A. Smith; Charlotte Allerton; Amit S. Kalgutkar; Han van de Waterbeemd; Don K. Walker, eds. (13 September 2012). Pharmacokinetics and Metabolism in Drug Design (3 ed.). John Wiley & Sons. pp. 24–. ISBN 978-3-527-64529-9. OCLC 1162264997.
Joseph T. DiPiro (2010). Concepts in Clinical Pharmacokinetics. ASHP. pp. 60–. ISBN 978-1-58528-241-8. OCLC 1058071530.
George Morrison Maxwell (6 December 2012). Principles of Paediatric Pharmacology. Springer Science & Business Media. pp. 35–. ISBN 978-1-4684-7544-9. OCLC 1012476802.

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[SmithAllertonKalgutkar2012-1] Dennis A. Smith; Charlotte Allerton; Amit S. Kalgutkar; Han van de Waterbeemd; Don K. Walker, eds. (13 September 2012). Pharmacokinetics and Metabolism in Drug Design (3 ed.). John Wiley & Sons. pp. 24–. ISBN 978-3-527-64529-9. OCLC 1162264997.

[DiPiro2010-2] Joseph T. DiPiro (2010). Concepts in Clinical Pharmacokinetics. ASHP. pp. 60–. ISBN 978-1-58528-241-8. OCLC 1058071530.

[Maxwell2012-3] George Morrison Maxwell (6 December 2012). Principles of Paediatric Pharmacology. Springer Science & Business Media. pp. 35–. ISBN 978-1-4684-7544-9. OCLC 1012476802.