Pharmasset

Pharmasset Inc. was a pharmaceutical company based in Princeton, New Jersey in the United States. The company develops antiviral drugs for HIV (including racivir), hepatitis B (including clevudine, marketed as Levovir), and hepatitis C.[1] In November 2011, Pharmasset was acquired by Gilead for $11.2 billion.[2]

Pharmasset Inc.
IndustryPharmaceuticals
Founded1998
Defunct2012
FateAcquired by Gilead Sciences in 2012
Headquarters
Princeton, New Jersey
,
United States
Key people
Raymond Schinazi
Dennis Liotta

History

Pharmasset was founded in 1998 by Raymond Schinazi and Dennis Liotta, scientists at Emory University. The company was initially incorporated in Barbados (as Pharmasset, Ltd.) and separately in Georgia. However, the company was redomiciled as a Delaware corporation on June 8, 2004.[3]

Pharmasset's initial public offering took place on April 27, 2007, when it was first listed on NASDAQ.[4] The firm's stock return in the first three fiscal quarters (nine months) of 2011 was 278 percent. Among analysts, 17 rated the company's stock as "strong buy" or "buy," while two rated it a "hold." Pharmasset was the best performer in this period among all major U.S. exchanges among stocks trading for at least $1.50 on January 1, 2011.[5]

Market

The company described itself as being a clinical-stage pharmaceutical company and stated that its primary focus is "the development of oral therapeutics for the treatment of hepatitis C virus."[6] The company's secondary focus was the development of Racivir, an investigational antiretroviral drug for the treatment of HIV. The company's research and development concentrated on nucleoside analogs.[7]

Pharmasset's PSI-7977 medication was further developed by Gilead and approved in December 2013 by the FDA as sofosbuvir (Sovaldi) for the treatment of chronic hepatitis C.[8]

Among Pharmasset's competitors were Abbott Laboratories,[9] Merck & Co., and Vertex Pharmaceuticals.[10]

Sovaldi
Main article: Sofosbuvir

Pharmasset originally developed Sofosbuvir (brand name Sovaldi).[11] When Gilead Sciences acquired Pharmasset for $11.2 billion in 2012, the "smaller company had forecast a $36,000 price per treatment course of Sovaldi. Gilead's investment bankers, Barclays and Bank of America Merrill Lynch did the "valuation of Pharmasset during merger talks and the related pricing assumptions for Sovaldi." According to The Wall Street Journal in response to the price of Solvadi at $84,000 per treatment course, the United States Senate Finance Committee wrote a letter to CEO John C. Martin questioning how much Pharmasset had spent on research and development on Sovaldi and how much Gilead spent on its "Sovaldi-related research costs since the 2012 buyout.[12]

References
  1. "Pharmasset Inc (VRUS:US)." Bloomberg.
  2. Tom Murphy (November 21, 2011). "Gilead Sciences to buy Pharmasset for $11 billion". Bloomberg Businessweek.
  3. Pharmasset Inc. Form 10-K Archived 2012-04-25 at the Wayback Machine (annual report filed 12/31/07 for the period ending 09/30/07).
  4. "Pharmasset Announces Second Fiscal Quarter 2007 Financial Results Archived 2012-04-25 at the Wayback Machine" (June 11, 2007) (press release). Pharmasset Inc.
  5. Brian Richards. "With 9 Months Down, These Are the Best Stocks of 2011" (October 3, 2011). The Motley Fool.
  6. "Corporate Overview - Pharmasset, Inc. Archived 2011-11-01 at the Wayback Machine." - Pharmasset, Inc.
  7. "About Us Archived 2011-10-11 at the Wayback Machine." Pharmasset Inc.
  8. "FDA approves Sovaldi for chronic hepatitis C". FDA New Release. U.S. Food and Drug Administration. 2013-12-06.
  9. Pat Wechsler, "Pharmasset Falls on Rival Abbott Hepatitis C Therapy Results" (October 21, 2011). Bloomberg.
  10. "Pharmasset expands hepatitis C trial; shares rise" (October 10, 2011). Reuters.
  11. "The lab breakthrough that paved the way for hepatitis C cures". STAT. 2016-09-13. Retrieved 2020-07-28.
  12. Staton, Tracy (14 July 2014). "Riled by $84,000 Sovaldi, Senate panel digs into Gilead's Pharmasset buy". Fierce Pharma. Retrieved 27 October 2015.
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