Benzylpenicilloyl polylysine

Benzylpenicilloyl polylysine (Pre-Pen) is used as a skin test before the administration of penicillin. It is used to detect the immunoglobulin E antibodies.[1][2] The chemical structure consists of the benzylpenicilloyl group attached to a polymer of L-lysine.[3][4][5]

Benzylpenicilloyl polylysine
Clinical data
Trade namesPre-Pen
Other namesPre-Pen
License data
Routes of
administration		Liquid intradermal
ATC code
  • none
Legal status
Legal status
Identifiers
IUPAC name
  • [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : L-Lysine homopolymer
CAS Number
DrugBank
ChemSpider
  • none
UNII
ChEMBL
CompTox Dashboard (EPA)
 NY (what is this?)  (verify)

References
  1. "Benzylpenicilloyl polylysine". PharmGKB.
  2. "Benzylpenicilloyl polylysine". DrugBank.
  3. Vemuri P, Harris KE, Suh LA, Grammer LC (2004). "Preparation of benzylpenicilloyl-polylysine: a preliminary study". Allergy and Asthma Proceedings. 25 (3): 165–168. PMID 15317320.
  4. Goldschmidt BM, Levine BB (June 1983). "The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy". The Journal of Antibiotics. 36 (6): 709–14. doi:10.7164/antibiotics.36.709. PMID 6874593.
  5. "PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen". DailyMed. U.S. National Library of Medicine.
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