Procoagulant platelets

Procoagulant platelets are a functional subgroup of platelets with distinct properties in physiological haemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation and parallelly gain pro-haemostatic function by retaining α-granule proteins on their membranes.[1] While a low level of procoagulant platelets is associated with impaired platelet function and bleeding diathesis high levels have been shown to worsen thrombotic events.[1][2]

References
  1. Aliotta, A; Alberio, L (Feb 24, 2021). "Thrombocytopathies: Not Just Aggregation Defects - The clinical relevance of Procoagulant Platelets". J Clin Med. 10 (5): 1–28. PMID 33668091.  This article incorporates text available under the CC BY 4.0 license.
  2. Agbani, E; Poole, A (Nov 16, 2017). "Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis". Blood. 130 (20): 2171–2179. PMID 28972013.


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