Products of conception

Products of conception, abbreviated POC, is a medical term used for the tissue derived from the union of an egg and a sperm. It encompasses anembryonic gestation (blighted ovum) which does not have a viable embryo.

Micrograph of products of conception. Chorionic villi (right of image) and cartilage, i.e. fetal parts (left of image). H&E stain.

In the context of tissue from a dilation and curettage, the presence of POC essentially excludes an ectopic pregnancy.

Retained products of conception

Retained products of conception is where products of conception remain in the uterus after childbirth, medical abortion or miscarriage (also known as spontaneous abortion).[1] Miscarriage with retained products of conception is termed delayed when no or very little products of conception have been passed, and incomplete when some products have been passed but some still remain in utero.[2][3]

Diagnosis
On gross pathology, the presence of chorionic villi (left) is diagnostic of products of conception, whereas decidua (right) is not.

The diagnosis is based on clinical presentation, quantitative HCG, ultrasound, and pathologic evaluation. A solid, heterogeneous, echogenic mass has a positive predictive value of 80%, but is present in only a minority of cases. A thickened endometrium of > 10 mm is usually considered abnormal, though no consensus exists on the appropriate cutoff. A cut-off of 8 mm or more has 34% positive rate, while a cut off of 14 mm or more has 85% sensitivity, 64% specificity for the diagnosis. Color Doppler flow in the endometrial canal can increased confidence in the diagnosis, though its absence does not exclude it, as 40% of cases of retained products have little or no flow. The differential in suspected cases includes uterine atony, blood clot, gestational trophoblastic disease, and normal post partum appearance of the uterus. Post partum blood clot is more common, reported in up to 24% of postpartum patients, and tends to be more hypoechoic than retained products with absent color flow on Doppler, and resolving spontaneously on follow up scans. The presence of gas raises the possibility of post partum endometritis, though this can also be seen in up to 21% of normal post pregnancy states. The normal post partum uterus is usually less than 2 cm in thickness, and continues to involute on follow up scans to 7 mm or less over time. Retained products are not uncommon, occurring in approximately 1% of all pregnancies, though it more common following abortions, either elective or spontaneous. There is significant overlap between appearance of a normal post partum uterus and retained products. If there is no endometrial canal mass or fluid, and endometrial thickness is less than 10 mm and without increased flow, retained products are statistically unlikely.[4][5][6]

Infections

Recent studies indicate that the products of conception may be susceptible to pathogenic infections,[7] including viral infections. Indeed, footprints of JC polyomavirus and Merkel cell polyomavirus have been detected in chorionic villi from females affected by spontaneous abortion as well as pregnant women.[8][9] Another virus, BK polyomavirus has been detected in the same tissues, but with lesser extent.[10]

Treatment

After medical abortion

According to the 2006 WHO Frequently asked clinical questions about medical abortion,[11] the presence of remaining products of conception in the uterus (as detected by obstetric ultrasonography) after a medical abortion is not an indication for surgical intervention (that is, vacuum aspiration or dilation and curettage). Remaining products of conception will be expelled during subsequent vaginal bleeding. Still, surgical intervention may be carried out on the woman's request, if the bleeding is heavy or prolonged, or causes anemia, or if there is evidence of endometritis.

In delayed miscarriage

In delayed miscarriage (also called missed abortion), the Royal Women's Hospital recommendations of management depend on the findings in ultrasonography:[12]

  • Gestational sac greater than 30-35mm, embryo larger than ~25mm (corresponding to 9+0 weeks of gestational age): Surgery is recommended. It poses a high risk of pain and bleeding with passage of products of conception. Alternative methods may still be considered.
  • Gestational sac 15-35mm, embryo smaller than 25mm (corresponding to between 7 and 9+0 weeks of gestational age): Medication is recommended. Surgery or expectant management may be considered.
  • Gestational sac smaller than 15-20mm, corresponding to a gestational age of less than 7 weeks: Expectant management or medication is preferable. The products of conception may be difficult to find surgically with a considerable risk of failed surgical procedure.

In incomplete miscarriage

In incomplete miscarriage, the Royal Women's Hospital recommendations of management depend on the findings in ultrasonography:[12]

  • Retained products of conception smaller than 15mm: Expectant management is generally preferable. There is a high chance of spontaneous expulsion.
  • Retained products of conception measuring between 15 and 20mm: Medical or expectant management are recommended. Surgery should only be considered upon specific indication.
  • At retained products of conception measuring over 35 to 50mm, the following measures are recommended:
  • Administration of misoprostol to hasten passage of products of conception.
  • Admission to inpatient care for observation for a few hours or overnight until the majority of the products of conception has passed and bleeding subsided.
  • After apparent failure of misoprostol, a gynecologic examination should be done prior to considering surgical evacuation of the uterus or the patient leaving the

See also

References
  1. Definition: 'Retained Products Of Conception' Archived 2016-03-04 at the Wayback Machine from MediLexicon. Retrieved Feb 2014.
  2. Hutchon, DJ (June 1997). "Missed abortion versus delayed miscarriage". British Journal of Obstetrics and Gynaecology. 104 (6): 753. doi:10.1111/j.1471-0528.1997.tb11994.x. PMID 9197887.
  3. MedlinePlus (October 25, 2004). "Abortion – incomplete". Medical Encyclopedia. Archived from the original on April 25, 2006. Retrieved May 24, 2006.
  4. Lee, NK; Kim, S; Lee, JW; Sol, YL; Kim, CW; Hyun Sung, K; Jang, HJ; Suh, DS (April 2010). "Postpartum hemorrhage: Clinical and radiologic aspects". European Journal of Radiology. 74 (1): 50–9. doi:10.1016/j.ejrad.2009.04.062. PMID 19477095.
  5. Wolman, I; Altman, E; Faith, G; Har-Toov, J; Amster, R; Gull, I; Jaffa, AJ (September 2009). "Combined clinical and ultrasonographic work-up for the diagnosis of retained products of conception". Fertility and Sterility. 92 (3): 1162–4. doi:10.1016/j.fertnstert.2009.01.087. PMID 19249022.
  6. Kamaya, A; Ro, K; Benedetti, NJ; Chang, PL; Desser, TS (September 2009). "Imaging and diagnosis of postpartum complications: sonography and other imaging modalities". Ultrasound Quarterly. 25 (3): 151–62. doi:10.1097/ruq.0b013e3181b5451e. PMID 19730078. S2CID 42844056.
  7. Contini C, Rotondo JC, Magagnoli F, Maritati M, Seraceni S, Graziano A (2018). "Investigation on silent bacterial infections in specimens from pregnant women affected by spontaneous miscarriage". J Cell Physiol. 34 (3): 433–440. doi:10.1002/jcp.26952. PMID 30078192.
  8. Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion". Hum Reprod. 34 (3): 433–440. doi:10.1002/jcp.27490. PMID 30590693. S2CID 53106591.
  9. Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Droplet-digital PCR assay to detect Merkel cell polyomavirus sequences in chorionic villi from spontaneous abortion affected females". J Cell Physiol. 235 (3): 1888–1894. doi:10.1002/jcp.29213. PMID 31549405.
  10. Tagliapietra A, Rotondo JC, Bononi I, Mazzoni E, Magagnoli F, Maritati M (2019). "Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion". Hum Reprod. 34 (3): 433–440. doi:10.1002/jcp.27490. PMID 30590693. S2CID 53106591.
  11. International Consensus Conference on Non-surgical (Medical) Abortion in Early First Trimester on Issues Related to Regimens and Service Delivery (2006). Frequently asked clinical questions about medical abortion (PDF). Geneva: World Health Organization. ISBN 978-92-4-159484-4. Archived from the original (PDF) on January 17, 2009.
  12. Clinical Practice Guideline: Miscarriage: Management Archived 2011-03-12 at the Wayback Machine from Royal Women's Hospital. Publication date: 7 October 2010.
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