RG7795

RG7795
Clinical data
Other names	RG-7795; ANA773; ANA-773
Legal status
Legal status	Investigational;
Identifiers
CAS Number	892498-64-5 ;
PubChem CID	11587892;
DrugBank	DB06329;
ChemSpider	9762656;
UNII	QTI86134YL;
Chemical and physical data
Formula	C12H14N4O5S
Molar mass	326.33 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(C=2C(S1)=CN=C(N)N2)[C@]3([C@H](OC(C)=O)C[C@@H](CO)O3)[H];
	InChI InChI=1S/C12H14N4O5S/c1-5(18)20-7-2-6(4-17)21-10(7)16-9-8(22-12(16)19)3-14-11(13)15-9/h3,6-7,10,17H,2,4H2,1H3,(H2,13,14,15)/t6-,7+,10+/m0/s1; Key:HOOMGTNENMZAFP-NYNCVSEMSA-N;

RG7795 (previously ANA773) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B.[1] It is an orally-available prodrug of isatoribine,[2] that was under development by Anadys Pharmaceuticals when it was acquired by Roche in 2011.[3] Its active metabolite is an agonist of TLR7; activation of TLR7 causes secretion of endogenous type 1 interferons, which have antiviral activity.[2]

Chemical structure of isatoribine

As of 2021, development of RG7795 appears to be discontinued.[4]

References

"RG 7795". AdisInsight. Springer Nature Switzerland AG. Retrieved 28 August 2017.
Funk E, Kottilil S, Gilliam B, Talwani R (May 2014). "Tickling the TLR7 to cure viral hepatitis". Journal of Translational Medicine. 12: 129. doi:10.1186/1479-5876-12-129. PMC 4039542. PMID 24884741.
"Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration". Genetic Engineering News. August 3, 2016.
Sachin Bhagchandani, Jeremiah A.Johnson, and Darrell J.Irvine (2021). "Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants". Advanced Drug Delivery Reviews. 175: 113803. doi:10.1016/j.addr.2021.05.013. PMC 9003539. PMID 34058283.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[Adis-1] "RG 7795". AdisInsight. Springer Nature Switzerland AG. Retrieved 28 August 2017.

[Funk-2] Funk E, Kottilil S, Gilliam B, Talwani R (May 2014). "Tickling the TLR7 to cure viral hepatitis". Journal of Translational Medicine. 12: 129. doi:10.1186/1479-5876-12-129. PMC 4039542. PMID 24884741.

[3] "Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration". Genetic Engineering News. August 3, 2016.

[4] Sachin Bhagchandani, Jeremiah A.Johnson, and Darrell J.Irvine (2021). "Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants". Advanced Drug Delivery Reviews. 175: 113803. doi:10.1016/j.addr.2021.05.013. PMC 9003539. PMID 34058283.{{cite journal}}: CS1 maint: multiple names: authors list (link)