Reflux suppressant

A reflux suppressant is any one of a number of drugs used to combat oesophageal reflux.[1][2] Commonly, following ingestion a 'raft' of alginic acid is created, floating on the stomach contents by carbon dioxide released by the drug. This forms a mechanical barrier to further reflux. Some preparations also contain antacids to protect the oesophagus.[3]

Reflux can also be coincidentally reduced by the motility stimulants and antidopaminergics.

References

Dettmar, P.W.; Hampson, F.C.; Taubel, J.; Lorch, U.; Johnstone, L.M.; Sykes, J.; Berry, P.J. (2007). "The suppression of gastro‐oesophageal reflux by alginates". International Journal of Clinical Practice. 61 (10): 1654–1662. doi:10.1111/j.1742-1241.2007.01524.x. PMID 17681004. S2CID 11035501.
Strugala, V.; Dettmar, P.W. (2010). "Alginate in the treatment of extra-oesophageal reflux". Effects, Diagnosis and Management of Extra-Esophageal Reflux. pp. 145–168.
Dettmar, P.W.; Little, S.L.; Baxter, T. (2005). "The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate". Journal of International Medical Research. 33 (3): 301–308. doi:10.1177/147323000503300305. PMID 15938591. S2CID 39712911.

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[1] Dettmar, P.W.; Hampson, F.C.; Taubel, J.; Lorch, U.; Johnstone, L.M.; Sykes, J.; Berry, P.J. (2007). "The suppression of gastro‐oesophageal reflux by alginates". International Journal of Clinical Practice. 61 (10): 1654–1662. doi:10.1111/j.1742-1241.2007.01524.x. PMID 17681004. S2CID 11035501.

[2] Strugala, V.; Dettmar, P.W. (2010). "Alginate in the treatment of extra-oesophageal reflux". Effects, Diagnosis and Management of Extra-Esophageal Reflux. pp. 145–168.

[3] Dettmar, P.W.; Little, S.L.; Baxter, T. (2005). "The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate". Journal of International Medical Research. 33 (3): 301–308. doi:10.1177/147323000503300305. PMID 15938591. S2CID 39712911.