Storiform pattern

A storiform, cartwheel or whorled pattern is a sign in histopathology. Microscopically, storiform arrangements appear to have center points that radiate cells or connective tissue outward. Storiform patterns may be irregular and, at lower magnification, can cause tissue to appear tangled into clumps.[1] The name "storiform" originates from Latin storea (woven), as storiform tissue tends to resemble woven fabric on microscopy.

Histopathology of whirled or woven pattern, comparing to a plant whorl and woven fabric. HE stain of ovarian stroma.

Skin tumors that can be classified as "storiform," having spindle cells with elongated nuclei radiating from a center point, are mainly:[2]

Storiform fibrosis is a histologic sign of IgG4-related disease, accompanied by a dense lymphoplasmocytic infiltrate, often a partially eosinophilic infiltrate and obliterative phlebitis.[1][3]

  • Dermatofibrosarcoma protuberans. HE stain.
  • A collagenoma, having a cartwheel or woven appearance.

References
  1. Stone, John H.; Zen, Yoh; Deshpande, Vikram (2012). "IgG4-Related Disease". The New England Journal of Medicine. 366: 539–551. doi:10.1056/NEJMra1104650.
  2. Choi, Joon Hyuk; Ro, Jae Y. (2018). "Cutaneous Spindle Cell Neoplasms: Pattern-Based Diagnostic Approach". Archives of Pathology & Laboratory Medicine. 142 (8): 958–972. doi:10.5858/arpa.2018-0112-RA. ISSN 0003-9985. PMID 30040457.
  3. Deshpande, Vikram; Zen, Yoh; Chan, John K.C.; et al. (2012). "Consensus statement on the pathology of IgG4-related disease". Modern Pathology. 25: 1181–1192. doi:10.1038/modpathol.2012.72.
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