Sulmazole

Sulmazole is a cardiotonic drug.[1] Sulmazole has the chemical formula C14H13N3O2S[2] and a molecular weight of 287.34 g/mol.[2]

Sulmazole
Identifiers
IUPAC name
  • 2-(2-Methoxy-4-methylsulfinylphenyl)-1H-imidazo[4,5-b]pyridine
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.070.348
Chemical and physical data
FormulaC14H13N3O2S
Molar mass287.34 g·mol−1
3D model (JSmol)
SMILES
  • COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=CC=N3

Sulmazole has been shown to improve cardiac index and reduce pulmonary capillary wedge pressure without significant changes in a person's heart rate or arterial pressure.[3] Sulmazole inhibits the A1 adenosine receptor and functionally blocks Gi, an inhibitory regulator.[1] Sulmazole is also a phosphodiesterase inhibitor.[3] Sulmazole is classified as an imidazopyridine and a sulfoxide.[2] Sulmazole can be taken intravenously or orally.[3] Side effects from sulmazole include blurring vision and temporary color blindness.[3]

References
  1. Parsons WJ, Ramkumar V, Stiles GL (April 1988). "The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi". Molecular Pharmacology. 33 (4): 441–8. PMID 3128727.
  2. PubChem. "Sulmazole". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-09-30.
  3. "NCATS Inxight: Drugs — SULMAZOLE". drugs.ncats.io. Retrieved 2019-09-30.
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