Suppressor-inducer T cell

Suppressor-inducer T cells are a specific subset of CD4+ T helper cells that "induce" CD8+ cytotoxic T cells to become "suppressor" cells.[1] Suppressor T cells are also known as CD25+–Foxp3+ regulatory T cells (nTregs), and reduce inflammation.[2][3]

References
  1. Negoro T, Iinuma F, Watanabe M (February 1996). "Cellular induction mechanism of CD8+ suppressor T cells by DMBA and TPA: formation of CD4+ suppressor-inducer T cells". Cell. Immunol. 167 (2): 216–23. doi:10.1006/cimm.1996.0029. PMID 8603430.
  2. Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM (August 2006). "The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells". Immunol. Rev. 212: 60–73. doi:10.1111/j.0105-2896.2006.00415.x. PMID 16903906.
  3. Mottet C, Golshayan D (November 2007). "CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use". Swiss Med Wkly. 137 (45–46): 625–34. PMID 18027108.


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