Toker cell

A Toker cell is an epithelial cell with clear cytoplasm in the nipple of some women.[1] Toker cells are believed to develop from sebaceous glands.[1] They are cytokeratin 7 (CK7) positive, in contrast to squamous epithelium.[1] Rarely, they can be numerous and atypical, and difficult to distinguish from malignant cells of Paget's disease of the breast.[2] In such cases, immunohistochemistry using CD138 and p53 can be used for distinction, both being negative in Toker cells and positive in Paget's disease.[2]

References

Saeed, Duaa; Shousha, Sami (2014). "Toker cells of the nipple are commonly associated with underlying sebaceous glands but not with lactiferous ducts". Journal of Clinical Pathology. 67 (11): 1010–1012. doi:10.1136/jclinpath-2014-202280. ISSN 0021-9746. PMID 25086135. S2CID 31216111.
Di Tommaso, Luca; Franchi, Giada; Destro, Annarita; Broglia, Fabiana; Minuti, Francesco; Rahal, Daoud; Roncalli, Massimo (2008). "Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases". Human Pathology. 39 (9): 1295–1300. doi:10.1016/j.humpath.2008.01.018. ISSN 0046-8177. PMID 18614197.

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[SaeedShousha2014-1] Saeed, Duaa; Shousha, Sami (2014). "Toker cells of the nipple are commonly associated with underlying sebaceous glands but not with lactiferous ducts". Journal of Clinical Pathology. 67 (11): 1010–1012. doi:10.1136/jclinpath-2014-202280. ISSN 0021-9746. PMID 25086135. S2CID 31216111.

[Di_TommasoFranchi2008-2] Di Tommaso, Luca; Franchi, Giada; Destro, Annarita; Broglia, Fabiana; Minuti, Francesco; Rahal, Daoud; Roncalli, Massimo (2008). "Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases". Human Pathology. 39 (9): 1295–1300. doi:10.1016/j.humpath.2008.01.018. ISSN 0046-8177. PMID 18614197.