Tooth regeneration

Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells.[1]

As a source of the new bioengineered teeth, somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer[2] in the shape of the new tooth.[3]

History

Young et al.[4] first demonstrated in 2002 that teeth could be regenerated from cells.

See also

References
  1. Keishi Otsu; Mika Kumakami-Sakano; Naoki Fujiwara; Kazuko Kikuchi; Laetitia Keller; Hervé Lesot; Hidemitsu Harada (February 4, 2014). "Stem cell sources for tooth regeneration: current status and future prospects". Frontiers in Physiology. 5: 36. doi:10.3389/fphys.2014.00036. PMC 3912331. PMID 24550845.
  2. Biopolymer methods in tissue engineering
  3. Hill, David J. (2012-05-10). "Toothless no more – Researchers using stem cells to grow new teeth". Singularity Hub. Retrieved June 16, 2014.
  4. Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC (2002). "Tissue engineering of complex tooth structures on biodegradable polymer scaffolds". J Dent Res. 81 (10): 695–700. doi:10.1177/154405910208101008. PMID 12351668. S2CID 21891790.


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