Topical tac

TAC stands for tetracaine, adrenaline, and cocaine, it was introduced by Pryor et al. in 1980. TAC is a topical anesthetic[1] solution for local anesthesia and is recommended for use on pediatric patients.[2][3]

Due to drug diversion concerns surrounding the use of cocaine in medicine, the cocaine was replaced with lidocaine and a new anesthetic was created - lidocaine, epinephrine, and tetracaine (LET).[4]

References
  1. Tipton, G. A.; DeWitt, G. W.; Eisenstein, S. J. (1 November 1989). "Topical TAC (tetracaine, adrenaline, cocaine) solution for local anesthesia in children: prescribing inconsistency and acute toxicity". Southern Medical Journal. 82 (11): 1344–1346. doi:10.1097/00007611-198911000-00004. PMID 2814620.
  2. Anderson, A. B.; Colecchi, C.; Baronoski, R.; DeWitt, T. G. (May 1990). "Local anesthesia in pediatric patients: topical TAC versus lidocaine". Annals of Emergency Medicine. 19 (5): 519–522. doi:10.1016/s0196-0644(05)82182-1. ISSN 0196-0644. PMID 2184706. S2CID 72722229.
  3. Königs, Ingo; Wenskus, Julia; Boettcher, Johannes; Reinshagen, Konrad; Boettcher, Michael (December 2020). "Lidocaine-Epinephrine-Tetracaine Gel Is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study". European Journal of Pediatric Surgery. 30 (6): 512–516. doi:10.1055/s-0039-3400283. ISSN 1439-359X. PMID 31739347.
  4. Achar, Suraj; Kundu, Suriti (2002-07-01). "Principles of Office Anesthesia Part II: Topical Anesthesia". American Family Physician. 66 (1): 99–102. ISSN 0002-838X. PMID 12126037.
  • Tipton GA, DeWitt GW, Eisenstein SJ (November 1989). "Topical TAC (tetracaine, adrenaline, cocaine) solution for local anesthesia in children: prescribing inconsistency and acute toxicity". Southern Medical Journal. 82 (11): 1344–6. doi:10.1097/00007611-198911000-00004. PMID 2814620.
  • US patent 5942543, Ernst, Amy A., "Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use", issued August 24, 1999


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