Tubulointerstitial nephritis and uveitis

Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney).

Tubulointerstitial nephritis and uveitis
Other namesAcute tubulointerstitial nephritis and uveitis syndrome
SpecialtyOphthalmology

Symptoms and signs

Uveitis may cause pain of the affected eye together with changes in vision. It may be accompanied by nonspecific systemic symptoms such as fever, involuntary weight loss, fatigue, loss of appetite, abdominal pain, and joint pains.[1]

Laboratory diagnosis We can see increased eosinophils under microscope after biopsy.

Management

History

It was first described in 1975.[1][2]

References
  1. Mackensen, F; Billing, H (November 2009). "Tubulointerstitial nephritis and uveitis syndrome". Current Opinion in Ophthalmology. 20 (6): 525–31. doi:10.1097/ICU.0b013e3283318f9a. PMID 19752730. S2CID 11461472.
  2. Dobrin, RS; Vernier, RL; Fish, AL (September 1975). "Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome". The American Journal of Medicine. 59 (3): 325–33. doi:10.1016/0002-9343(75)90390-3. PMID 1163543.
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