U937 (cell line)

U-937 cells are a model cell line used in biomedical research.[1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient [2] and are used to study the behaviour and differentiation of monocytes. U-937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of mature macrophages.

U-937 cells are of the myeloid lineage and so secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF independently promote IL-10 production in U937 cells.[3]

The HLA alleles present in U-937 cells are HLA-A*03:01, A*31:01, B*18:01, B*51:01, Cw*01:02 and Cw*07:02.[4]

References
  1. ATCC U-937 CRL-1593.2™ https://www.atcc.org/products/crl-1593.2
  2. Sundström C (May 1976). "Establishment and characterization of a human histiocytic lymphoma cell line (U-937)". Int. J. Cancer. 17 (5): 565–77. doi:10.1002/ijc.2910170504. PMID 178611.
  3. Lehmann MH (June 1998). "Recombinant human granulocyte-macrophage colony-stimulating factor triggers interleukin-10 expression in the monocytic cell line U937". Mol. Immunol. 35 (8): 479–485. doi:10.1016/S0161-5890(98)00043-1. PMID 9798652.
  4. Gebreselassie D (November 2006). "Sampling of major histocompatibility complex class I-associated peptidome suggests relatively looser global association of HLA-B*5101 with peptides". Hum. Immunol. 67 (11): 894–906. doi:10.1016/j.humimm.2006.08.294. PMC 2269730. PMID 17145369.
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