Verocay body

Verocay bodies were first described by Uruguayan neuro-pathologist José Juan Verocay (born: 16 June 1876, Nuevo Paysandú, Uruguay; died: 1927) in 1910. It is a required histopathological finding for diagnosing schwannomas.

Antoni A area of schwannoma with Verocay bodies (one annotated by circle)

Verocay bodies are a component of "Antoni A" which are the dense areas of schwannomas located between palisading spindle cells found in neoplasms. Two nuclear palisading regions and an anuclear zone make up one Verocay body.[1]

Originally Verocay bodies were called 'neuromas', a term coined by Louis Odier in 1803. The name changed to ‘neuro-fibroma’ under Von Recklinghausen and later in 1935 to ‘neurilemmomas’ under Arthur Purdy Stout. When Harkin and Reed coined the term 'schwannoma' in 1968, Verocay bodies received their present-day name.[2]

Features on histopathological examination include:

1. Eosinophilic acellular area due to overexpression of lamins.[3]

2. Consisting of reduplicated basement membrane and cytoplasmic processes.[4]

References
  1. Joshi, Rajiv (2012). "Learning from eponyms: Jose Verocay and Verocay bodies, Antoni A and B areas, Nils Antoni and Schwannomas". Indian Dermatology Online Journal. 3 (3): 215–219. doi:10.4103/2229-5178.101826. PMC 3505436. PMID 23189261.
  2. Wippold FJ, 2nd; Lämmle, M; Anatelli, F; Lennerz, J; Perry, A (November 2006). "Neuropathology for the neuroradiologist: palisades and pseudopalisades". American Journal of Neuroradiology. 27 (10): 2037–41. PMC 7977220. PMID 17110662.
  3. Joshi, Rajiv (2012). "Learning from eponyms: Jose Verocay and Verocay bodies, Antoni A and B areas, Nils Antoni and Schwannomas". Indian Dermatology Online Journal. 3 (3): 215–219. doi:10.4103/2229-5178.101826. PMC 3505436. PMID 23189261.
  4. Pytel, Peter; Anthony, Douglas C. (2015). Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (eds.). Robbins and Cotran Pathologic Basis of Disease. Philadelphia, PA: Elsevier/Saunders. p. 1247. ISBN 978-1-4557-2613-4.


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