Zephyr Surgical Implants

Zephyr Surgical Implants (ZSI) is a Swiss-based medical device manufacturer that produces and distributes artificial urinary sphincters and penile implants worldwide. ZSI products are used in the management of moderate-to-severe urinary incontinence in men, erectile dysfunction, Peyronie's disease, penis enlargement, female-to-male gender reassignment surgery.

Zephyr Surgical Implants
TypePrivate
IndustryHealth care
Founded2005 (2005)
FounderChristophe Llorens (CEO)
Headquarters
Geneva
Area served
Worldwide
Key people
Raphael Llorens
Websitezsimplants.ch

History

The company was founded by Dr. Christophe Llorens and Raphael Llorens in 2005.[1] The first product – ZSI 375 artificial urinary sphincter was introduced in 2009.[2][3] As of 2019, more than 4500 ZSI 375 artificial urinary sphincters were implanted worldwide.[2] The inflatable penile implant designed for female-to-male gender assignment surgeries became available in the European market in March 2016, and the first phalloplasty procedures using ZSI 475 FtM implants were performed in June 2016.[4]

Clinical studies

Many clinical studies have been performed with the artificial urinary sphincter ZSI 375 in the treatment of moderate and severe stress incontinence, most of them are retrospective and non-randomized tests. Success rates in total or social continence vary, in a period of 6 to 24 months, between 68-89%.[5][6]

References
  1. Vakalopoulos, Ioannis; Kampantais, Spyridon; Laskaridis, Leonidas; Chachopoulos, Vasileios; Koptsis, Michail; Toutziaris, Chrysovalantis (2012). "New Artificial Urinary Sphincter Devices in the Treatment of Male Iatrogenic Incontinence". Advances in Urology. 2012 (Special Issue): 439372. doi:10.1155/2012/439372. PMC 3332164. PMID 22567002.
  2. Zephyr Surgical Implants (November 2019). ARTIFICIAL URINARY SPHINCTER ZSI 375 (PDF) (Second ed.). Geneva, Switzerland: Zephyr Surgical Implants. Retrieved 19 January 2020.
  3. Amend, Bastian; Toomey, Patricia; Sievert, Karl-Dietrich (2013). "Artificial sphincter". Current Opinion in Urology. 23 (6): 520–527. doi:10.1097/01.MOU.0000434591.02823.d0. PMID 24080811. Retrieved 19 January 2020.
  4. Neuville, Paul; Morel-Journel, Nicolas; Cabelguenne, Delphine; Ruffion, Alain; Paparel, Philippe; Terrier, Jean-Etienne (2019). "First Outcomes of the ZSI 475 FtM, a Specific Prosthesis Designed for Phalloplasty". The Journal of Sexual Medicine. 16 (2): 316–322. doi:10.1016/j.jsxm.2018.11.013. PMID 30638882. Retrieved 19 January 2020.
  5. Staerman, Frederic; G-Llorens, Christophe; Leon, Priscilla; Leclerc, Yves (April 2013). "ZSI 375 artificial urinary sphincter for male urinary incontinence: a preliminary study: ZSI 375 AUS: PRELIMINARY STUDY". BJU International. 111 (4b): E202–E206. doi:10.1111/j.1464-410X.2012.11468.x.
  6. "Efficacy of the Artificial Urinary Sphincter ZSI 375 for Treatment of Post-Radical Prostatectomy Incontinence in Patients with Intrinsic Sphincter Deficiency: A Preliminary Study". European Medical Journal. 2017-06-01. Retrieved 2022-07-22.
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