PRKG1

Proteína cinasa dependiente del GMPc tipo I
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Símbolo	cGK1 (HGNC: 9414)
Identificadores; externos	OMIM: 176894 ; EBI: cGK1; GeneCards: Gen cGK1; UniProt: cGK1; Bases de datos de enzimas IntEnz: entrada en IntEnz; BRENDA: entrada en BRENDA; ExPASy: NiceZime view; KEGG: entrada en KEEG; PRIAM: perfil PRIAM; ExplorEnz: entrada en ExplorEnz; MetaCyc: vía metabólica
Número EC	2.7.11.12
Locus	Cr. 10 q11.2
	Referencias: AmiGO / QuickGO
Estructura/Función proteica
Tamaño	671 (aminoácidos)
Ortólogos
Humano	Ratón
5592
Q13976	n/a
NM_001098512	n/a
;

La proteína cinasa GMPc dependiente tipo I (PRKG1) (EC 2.7.11.12) es una enzima codificada en humanos por el gen PRKG1.[1][2][3] Pertenece a la familia de las serina/treonina proteína cinasas específicas.

Interacciones

La proteína PRKG1 ha demostrado ser capaz de interaccionar con:

ITPR1[4]
RGS2[5]
TNNT1[6]
MRVI1[4][7]
GTF2I[8]

Referencias

Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Nov de 1989). «Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat». FEBS Lett 255 (2): 321-9. PMID 2792381.
Orstavik S, Sandberg M, Berube D, Natarajan V, Simard J, Walter U, Gagne R, Hansson V, Jahnsen T (Apr de 1992). «Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10». Cytogenet Cell Genet 59 (4): 270-3. PMID 1544322.
«Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I».
Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (Mar. de 2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta». Nature (ENGLAND) 404 (6774): 197-201. ISSN 0028-0836. PMID 10724174. doi:10.1038/35004606.
Tang, K Mary; Wang Guang-rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang (Dec. de 2003). «Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure». Nat. Med. (United States) 9 (12): 1506-12. ISSN 1078-8956. PMID 14608379. doi:10.1038/nm958.
Yuasa, K; Michibata H; Omori K; Yanaka N (Dec. de 1999). «A novel interaction of cGMP-dependent protein kinase I with troponin T». J. Biol. Chem. (UNITED STATES) 274 (52): 37429-34. ISSN 0021-9258. PMID 10601315.
Ammendola, A; Geiselhöringer A, Hofmann F, Schlossmann J (Jun. de 2001). «Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta». J. Biol. Chem. (United States) 276 (26): 24153-9. ISSN 0021-9258. PMID 11309393. doi:10.1074/jbc.M101530200.
Casteel, Darren E; Zhuang Shunhui, Gudi Tanima, Tang Julian, Vuica Milena, Desiderio Stephen, Pilz Renate B (Aug. de 2002). «cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I». J. Biol. Chem. (United States) 277 (35): 32003-14. ISSN 0021-9258. PMID 12082086. doi:10.1074/jbc.M112332200.

Datos: Q18030785

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[pmid2792381-1] Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Nov de 1989). «Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat». FEBS Lett 255 (2): 321-9. PMID 2792381.

[pmid1544322-2] Orstavik S, Sandberg M, Berube D, Natarajan V, Simard J, Walter U, Gagne R, Hansson V, Jahnsen T (Apr de 1992). «Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10». Cytogenet Cell Genet 59 (4): 270-3. PMID 1544322.

[entrez-3] «Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I».

[pmid10724174-4] Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (Mar. de 2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta». Nature (ENGLAND) 404 (6774): 197-201. ISSN 0028-0836. PMID 10724174. doi:10.1038/35004606.

[pmid14608379-5] Tang, K Mary; Wang Guang-rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang (Dec. de 2003). «Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure». Nat. Med. (United States) 9 (12): 1506-12. ISSN 1078-8956. PMID 14608379. doi:10.1038/nm958.

[pmid10601315-6] Yuasa, K; Michibata H; Omori K; Yanaka N (Dec. de 1999). «A novel interaction of cGMP-dependent protein kinase I with troponin T». J. Biol. Chem. (UNITED STATES) 274 (52): 37429-34. ISSN 0021-9258. PMID 10601315.

[pmid11309393-7] Ammendola, A; Geiselhöringer A, Hofmann F, Schlossmann J (Jun. de 2001). «Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta». J. Biol. Chem. (United States) 276 (26): 24153-9. ISSN 0021-9258. PMID 11309393. doi:10.1074/jbc.M101530200.

[pmid12082086-8] Casteel, Darren E; Zhuang Shunhui, Gudi Tanima, Tang Julian, Vuica Milena, Desiderio Stephen, Pilz Renate B (Aug. de 2002). «cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I». J. Biol. Chem. (United States) 277 (35): 32003-14. ISSN 0021-9258. PMID 12082086. doi:10.1074/jbc.M112332200.