Desmonema may mean:
- In the Regnum Animalia: Desmonema Agassiz, 1862 – genus of Scyphozoa (Cyaneidae)
- In the Regnum Plantae: Desmonema Raf. – genus of Euphorbiaceae, synonym of Euphorbia
- In the Regnum Plantae: Desmonema Miers – genus of Menispermaceae, synonym of Tinospora
- In the Regnum Bacteria: Desmonema M.J.Berkeley & Thwaites ex Bornet & Flahault, 1887 – Genus of Scytonemataceae
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