The taxon authority O'Brien may refer to:
- Charles W. O'Brien, U.S. entomologist
- Heath E. O'Brien, lichenologist
- James O'Brien (1842–1930, O'Brien), English botanist
- Lois B. O'Brien, U.S. entomologist
- Lorna J. O'Brien, Canadian palaeontologist
- Stephen James O'Brien (born 1944), U.S. zoologist
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