amphipathic
Physiology
Biology
(adjective)
Describing a molecule, such as a detergent, which has both hydrophobic and hydrophilic groups.
Examples of amphipathic in the following topics:
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Salt Formation
- Such molecules are termed amphiphilic (Gk. amphi = both) or amphipathic.
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Phospholipids
- Phospholipids are amphipathic molecules that make up the bilayer of the plasma membrane and keep the membrane fluid.
- A phospholipid is an amphipathic molecule which means it has both a hydrophobic and a hydrophilic component.
- The formation of a micelle is a response to the amphipathic nature of fatty acids, meaning that they contain both hydrophilic and hydrophobic regions.
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Antimicrobial Peptides
- This amphipathicity of the antimicrobial peptides allows the partition of the membrane lipid bilayer.
- Their amino acid composition, amphipathicity, cationic charge, and size allow them to attach to and insert into membrane bilayers to form pores by ‘barrel-stave', ‘carpet' or ‘toroidal-pore' mechanisms.
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Antimicrobial Proteins
- The amphipathicity (hydrophilic and hydrophobic ends) and positive charge of peptides are their defining structural features.
- The amino acid composition, amphipathicity, cationic charge, and size allow them to attach to and insert into membrane bilayers to form pores by barrel-stave, carpet, or toroidal-pore mechanisms.
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Soaps & Detergents
- Such molecules are termed amphiphilic (Gk. amphi = both) or amphipathic.
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Regulation of Blood Cholesterol Levels
- Phospholipids and cholesterol, being amphipathic, are transported in the surface monolayer of the lipoprotein particle.