vegf

(noun)

Signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate.

Related Terms

Examples of vegf in the following topics:

  • Angiogenesis and Disease

    • ., VEGF).
    • In 2007, it was discovered that cancerous cells stop producing the anti-VEGF enzyme PKG.
    • Overexpression of VEGF causes increased permeability in blood vessels in addition to stimulating angiogenesis.
    • In wet macular degeneration, VEGF causes proliferation of capillaries into the retina.
    • A novel treatment of this disease is to use a VEGF-inhibiting siRNA to stop the main signaling cascade for angiogenesis.

  • Platelet Plug Formation

    • The released chemicals include ADP, VWF, thromboxane A2, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), serotonin, and coagulation factors.
    • PDGF and VEGF are involved in angiogenesis, the growth of new blood vessels and cell cycle proliferation (division) following injury.

  • Platelets

    • They also release wound healing-associated growth factors including platelet-derived growth factor (PDGF), which directs cell movement; TGF beta, which stimulates the deposition of extracellular matrix tissue into a wound during healing; and vascular endothelial growth factor (VEGF), which stimulates angiogenesis, or the regrowth of blood vessels.

  • Clot Retraction and Repair

    • Then new blood vessels grow into the healing tissue in a process called angiogenesis, which is stimulated by vascular endothelial growth factor (VEGF).

  • Development of Blood

    • Angiogenesis also contributes to the complexity of the initial network; endothelial buds form by an extrusion-like process which is prompted by the expression of vascular endothelial growth factor (VEGF).