Concept
Version 13
Created by Boundless
Clonal Selection and T-Cell Differentiation
Clonal selection of lymphocytes
A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce lymphocytes in the immune system. Clonal selection of lymphocytes: 1) A hematopoietic stem cell undergoes differentiation and genetic rearrangement to produce 2) immature lymphocytes with many different antigen receptors. Those that bind to 3) antigens from the body's own tissues are destroyed, while the rest mature into 4) inactive lymphocytes. Most of these will never encounter a matching 5) foreign antigen, but those that do are activated and produce 6) many clones of themselves.
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