Section 5
Cancer and Gene Regulation
Book
Version 32
By Boundless
By Boundless
Boundless Biology
Biology
by Boundless
5 concepts
![Thumbnail](../../../../../../figures.boundless-cdn.com/48/square/e7-rb.gif)
Altered Gene Expression in Cancer
Cancer, a disease of altered gene expression, is the result of gene mutations or dramatic changes in gene regulation.
![Thumbnail](../../../../../../figures.boundless-cdn.com/20563/raw/ions-in-tumour-progression.jpg)
Epigenetic Alterations in Cancer
Common in cancer cells, silencing genes, which occur through epigenetic mechanisms, include modifications to histone proteins and DNA.
![Thumbnail](../../../../../../figures.boundless-cdn.com/20349/raw/transcription-factors.jpg)
Cancer and Transcriptional Control
Increased transcriptional activation of genes result in alterations of cell growth leading to abnormal gene expression, as seen in cancer.
![Thumbnail](../../../../../../figures.boundless-cdn.com/20351/raw/mirna.jpg)
Cancer and Post-Transcriptional Control
Modifications, such as the overexpression of miRNAs, in the post-transcriptional control of a gene can result in cancer.
![Thumbnail](../../../../../../figures.boundless-cdn.com/6118/square/ogy-282-29-her2-expression.jpeg)
Cancer and Translational Control
Cancer can arise from translational or post-translational modifications of proteins.