Section 2
Chromosomal Basis of Inherited Disorders
Book
Version 32
By Boundless
By Boundless
Boundless Biology
Biology
by Boundless
3 concepts
![Thumbnail](../../../../../../figures.boundless-cdn.com/18946/square/figure-13-03-02.jpg)
Disorders in Chromosome Number
Aneuploidy, an abnormal number of chromosomes in a cell, is caused by nondisjunction, or the failure of chromosomes to separate at meiosis.
![Thumbnail](../../../../../../figures.boundless-cdn.com/18949/square/figure-13-03-07.jpeg)
Chromosomal Structural Rearrangements
Structural rearrangements of chromosomes include both inversions and translocations, which may have detrimental effects on an organism.
![Thumbnail](../../../../../../figures.boundless-cdn.com/20681/square/klinefelter-27s-syndrome.jpeg)
X-Inactivation
The presence of extra X chromosomes in a cell is compensated for by X-inactivation in which all but one X chromosome are silenced.