inclusion body
(noun)
Inclusion bodies are nuclear or cytoplasmic aggregates of stainable substances, usually proteins.
Examples of inclusion body in the following topics:
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Cell Inclusions and Storage Granules
- Protein inclusion bodies are classically thought to contain misfolded protein.
- However, this has recently been contested, as green fluorescent protein will sometimes fluoresce in inclusion bodies, which indicates some resemblance of the native structure and researchers have recovered folded protein from inclusion bodies.
- When genes from one organism are expressed in another the resulting protein sometimes forms inclusion bodies.
- This electron micrograph shows the rabies virus, as well as Negri bodies, or cellular inclusions.
- Explain the hypothesis regarding the formation of inclusion bodies and the importance of storage granules
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Chlamydiae
- Most intracellular chlamydiae are located in an inclusion body or vacuole .
- Light microscope view of cells infected with chlamydiae as shown by the brown inclusion bodies.
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Viral Exit
- Virus assembly depends on the site of synthesis and such sites are the nucleus, endoplasmic reticulum, and the Golgi apparatus aka Golgi body.
- Aside from this, assembly also occurs in the viroplasm which is an inclusion body in a cell.
- The viral envelope is the typical lipid bilayer, derived from the host cell itself and sources usually come from the nuclear membrane, endoplasmic reticulum, Golgi apparatus/body, and plasma membrane.
- Excess capsids are formed and inclusion bodies may be seen in the cytoplasm.
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Special Culture Techniques
- They are particularly susceptible due to their unusually low body temperature, which is hospitable to the leprosy bacterium, Mycobacterium leprae.
- The leprosy bacterium is difficult to culture and armadillos have a body temperature of 34°C, similar to human skin.
- Light microscope view of cells infected with chlamydiae as shown by the brown inclusion bodies.
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Chemical Analysis of Microbial Cytoplasm
- These inclusions are characterized by their granular appearance and insolubility.
- Typically, inclusions function as reserve materials.
- E. coli offers another example of bacterial inclusions.
- These E. coli inclusions are composed of protein aggregates.
- In addition, inclusions can contain phosphate reserves, sulfur reserves, or photosynthetic pigments.
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Bacterial Polyesters
- The yield of PHA obtained from the intracellular inclusions can be as high as 80% of the organism's dry weight .
- PHAs are processed mainly via injection molding, extrusion and extrusion bubbles into films and hollow bodies.
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Classification of Microorganisms
- The first, largest, and most inclusive group under which organisms are classified is called a domain and has three subgroups: bacteria, archae, and eukarya.
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Classification and Nomenclature
- Classification is the grouping of organisms into progressively more inclusive groups based on phylogeny and phenotype.
- For bacteria, valid names must have a Latin or Neolatin name and can only use basic latin letters (w and j inclusive, see History of the Latin alphabet for these), consequently hyphens, accents and other letters are not accepted and should be translitterated correctly (e.g. ß=ss).
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Classification and Identification of Helminths
- The classification and identification of helminths are dependent on numerous factors including body shape, body cavity, body covering, digestive tubing, sex and type of attachment organs.
- They lack a body cavity and have a tegument body covering.
- Trematodes are characterized by an unsegmented plane for body shape.
- They also lack a body cavity and have a tegument for body covering.
- Nematodes are characterized by a cylindrical body shape and do indeed have a body cavity.
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Starvation-Induced Fruiting Bodies
- Starvation-induced fruiting bodies can aggregate up to 500 micrometres long and contain approximately 100,000 bacterial cells.
- In these fruiting bodies, the bacteria perform separate tasks; this type of cooperation is a simple type of multicellular organisation.
- These fruiting bodies can take different shapes and colors, depending on the species.
- Within the fruiting bodies, cells begin as rod-shaped vegetative cells and develop into rounded myxospores with thick cell walls.
- At a molecular level, initiation of fruiting body development is regulated by Pxr sRNA.