open reading frame

(noun)

A sequence of DNA triplets, between the initiator and terminator codons, that can be transcribed into mRNA and later translated into protein.

Related Terms

Examples of open reading frame in the following topics:

  • Size Variation and ORF Contents in Genomes

    • An open reading frame (ORF) is the part of a reading frame that varies in size and content in bacterial genomes.
    • In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons.
    • Open reading frames are used as one piece of evidence to assist in gene prediction.
    • Even a long open reading frame by itself is not conclusive evidence for the presence of a gene.
    • In this sequence two out of three possible reading frames are entirely open, meaning that they do not contain a stop codon:

  • Unsticking Stuck Ribosomes

    • The tmRNP binds to the A-site, allowing the ribosome to switch templates from the broken message onto the open reading frame of the tmRNA via the resume codon (blue GCA).

  • Respiratory Syncytial Virus Infection

    • There are two open reading frames of M2.

  • Temperate Bacteriophages: Lambda and P1

    • Note how sib is displaced by the recombination event from the N extended PL promoter open reading frame.

  • Double-Stranded DNA Viruses: Herpesviruses

    • HSV-1 and HSV-2 each contain at least 74 genes within their genomes, although speculation over gene crowding allows as many as 84 unique protein-coding genes by 94 putative pen reading frames.