National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Klatskin tumor

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My mom has been diagnosed with a Klatskin tumor. They tried to remove it but were unable to do so. What symptoms might develop as her condition progresses? Her eyesight has become blurred. Could this be related to her condition?

The following information may help to address your question:


What are Klatskin tumors?

Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. It is the most common type of cholangiocarcinoma, accounting for more than half of all cases.[1][2][3][4] Symptoms usually don't present until advanced stages of disease, when jaundice is the most common feature. Other symptoms include abdominal pain, unintentional weight loss, and a general feeling of being unwell (malaise).[3][4] 

The cause of Klatskin tumors is unknown.[2] Studies suggest that a combination of genetic, environmental, and lifestyle factors (multifactorial) likely influence whether a person will develop cholangiocarcinoma. Because Klatskin tumors are often discovered after they have spread, they can be challenging to treat.[3] Surgical removal of the tumor and relief of bile duct blockage are the main goals of treatment.[1][2][4]
Last updated: 10/13/2016

What signs and symptoms may be associated with Klatskin tumors?

The symptoms associated with Klatskin tumors are usually due to blocked bile ducts. Symptoms may include:[1][2][3]
  • Jaundice
  • Itching
  • Light colored stools and/or dark urine
  • Abdominal pain
  • Loss of appetite / weight loss
  • Fever
  • Nausea / vomiting
Last updated: 10/13/2016

What symptoms are common in patients with non-resectable Klatskin tumors?

Two of the most common features noted in patients with non-resectable tumors are bile duct blockage (which can lead to jaundice, itching, and other symptoms) and pain.[1][2]
Last updated: 10/13/2016

Is blurred vision associated with Klatskin tumor progression?

A search of the resources available to us did not identify blurred vision as an associated finding in Klatskin tumors. We encourage you to discuss your concerns with your mom's health care providers.
Last updated: 10/13/2016

What is the prognosis for individuals with Klatskin tumors?

Most Klatskin tumors are diagnosed at an advanced stage.[1][2][3][4] The best long-term results are achieved with surgical intervention.[4] The median survival of patients with non-resectable Klatskin tumors after palliative drainage is two to eight months.[2] Complications include recurring bacterial cholangitis and/or liver failure (cirrhosis).[2] The aim of palliative treatment is improvement in the patient’s quality of life. This includes treating cholestasis and cholangitis, which secondarily prolongs survival.[5][6]
Last updated: 10/13/2016

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

Warm regards,
GARD Information Specialist

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  1. Bile Duct (Cholangiocarcinoma) Cancer. American Cancer Society. November 1, 2014; http://www.cancer.org/cancer/bileductcancer/detailedguide/.
  2. Darwin PE. Cholangiocarcinoma. Medscape Reference. August 9, 2016; http://emedicine.medscape.com/article/277393-overview.
  3. Cholangiocarcinoma. Genetics Home Reference (GHR). August 2016; https://ghr.nlm.nih.gov/condition/cholangiocarcinoma.
  4. Furuse J. Klatskin tumor. Orphanet. September 2012; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=99978.
  5. Lillemoe KD. Klatskin tumors. Surgical Treatment: Evidence-Based and Problem-Oriented. 2001;
  6. Witzigmann H, Wiedmann M, Wittekind C, Mossner J, Hauss J. Therapeutical Concepts and Results for Klatskin Tumors. Dtsch Arztebl Int. Feb 2008; 105(9):156-161. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696740/?tool=pubmed.