The following information may help to address your question:
What is Ménétrier disease?
Ménétrier disease is a gastrointestinal condition characterized by overgrowth of the mucous
cells (foveola) in the mucous membrane lining the stomach, causing enlarged gastric folds.
[1] This leads to excessive mucus production, causing
protein loss from the stomach and low or absent levels of stomach acid.
[2] Symptoms may include pain in the upper middle region of the stomach, nausea, vomiting, and diarrhea.
[1] The cause of Ménétrier disease is largely not known, although some cases are associated with infection, particularly pediatric cases, which can be caused by
CMV infections. Treatment may include medications such as
cetuximab and
gastrectomy in severe cases.
[1][2]
Last updated: 6/1/2016
What are the signs and symptoms of Ménétrier disease?
The symptoms of Ménétrier disease may vary from individual to individual. While some individuals may not experience any symptoms, the most common symptom is pain in the upper middle region of the stomach (epigastric pain). Other symptoms may include:
[1][3]
- Weight loss
- Nausea and vomiting
- Gastrointestinal bleeding
- Diarrhea
- Edema
Last updated: 6/1/2016
What causes Ménétrier disease?
Last updated: 6/1/2016
Is Ménétrier disease genetic?
Although the cause of Ménétrier disease is unknown, several cases of the condition have been reported in a
familial setting. In a 2003 journal article titled "An unusual expression of hyperplastic gastropathy (Menetrier type) in twins," Ibarrola
et al. described the first documented example of an occurrence in twins. They suggest that these two cases suggest the possibility of a
genetic predisposition for this condition.
[5] There have been several other reports of familial occurrences. You can read more about these cases by
clicking here to access the information page on Ménétrier disease from Online
Mendelian Inheritance in Man (OMIM).
If you are concerned about a
family history of Ménétrier disease, we would recommend consulting with a genetics professional.
Last updated: 6/1/2016
How can I find a genetics professional in my area?
Last updated: 12/6/2017
How might Ménétrier disease be treated?
No one treatment has proven effective for all patients with Ménétrier disease. In milder cases, treatment may be supportive with a recommended high protein diet to offset loss of protein. Other treatment options for moderate or more severe cases may include: Treatment of underlying
CMV/
Helicobacter pylori (H. Pylori) infection; medications such as Gastric antisecretory agents (
protein pump inhibitors),
octreotide, and
cetuximab; and a
gastrectomy.
[3]
Last updated: 6/1/2016
What is the long-term outlook for Ménétrier disease?
The
prognosis of Ménétrier disease varies from person to person. Resolution of symptoms may occur in adults with an underlying
Helicobacter Pylori (H. Pylori) infection once treatment of the infection occurs. Cases in children may resolve spontaneously or with treatment of the underlying
CMV infection.
Although it has been suggested that patients with Ménétrier disease may be at an increased risk of developing stomach
cancer; the risk remains uncertain. Studies estimate that between 2% and 15% of individuals with Ménétrier disease may develop stomach cancer in their lifetime. Given this potential, some authors suggest surveillance with annual or biannual
endoscopy.
[3]
Last updated: 6/1/2016
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please
contact us.
Warm regards,
GARD Information Specialist
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