Klippel-Trenaunay syndrome

It is our understanding that Klippel-Trenaunay syndrome is not always a stable disease. Some patients who have not experienced any progression of their disease for years, may notice a change in their symptoms at some point as they age. [1]

In some cases, women have reported an increase in symptoms during times of hormonal change such as puberty, menopause, perimenopause and pregnancy. These symptoms may include increased swelling of the affected limb, tingling sensation/pain, change in color and heaviness in the affected limb, fatigue, headache, heart palpitations, exercise intolerance, and increase in clotting times. [2] If progression of the disease arises, it is strongly recommended to be evaluated by a physician to rule out any serious complications.