National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Russell-Silver syndrome

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What is the average lifespan for a male with Russell-Silver syndrome?
The long-term outlook associated with Russell-Silver syndrome is generally good,[1] but may depend on how severely affected a person is and whether complications arise. People with RSS may face challenges from birth to adulthood. While some people with RSS believe that they are not at risk for associated health issues once they reach their adult height, recent research has shown there may be increased risks for certain health issues in adulthood. These possible risks include:[2]
  • Metabolic syndrome
  • Uterine and vaginal dysgenesis (in females with 11p15-related RSS)
  • Gonadal hypofunction or testicular cancer in males
  • Low muscle mass or low bone mineral density
  • Myoclonus dystonia (in people with chromosome 7-related RSS)
Last updated: 6/29/2017

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  1. Toutain A. Orphanet. September, 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=813.
  2. Russell Silver Syndrome. The MAGIC Foundation. 2018; https://www.magicfoundation.org/Growth-Disorders/Russell-Silver-Syndrome/.