National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Herpes simplex encephalitis



Other Names:
Herpetic encephalitis; Herpes simplex meningo-encephalitis; Herpes simplex neuroinvasion; Herpetic encephalitis; Herpes simplex meningo-encephalitis; Herpes simplex neuroinvasion; HSV encephalitis; Herpes simplex virus encephalitis; HSE; HSVE See More
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Herpes simplex encephalitis is a rare neurological condition that is characterized by inflammation of the brain (encephalitis). People affected by this condition may experience a headache and fever for up to 5 days, followed by personality and behavioral changes; seizures; hallucinations; and altered levels of consciousness. Without early diagnosis and treatment, severe brain damage or even death may occur. Herpes simplex encephalitis is caused by a virus called the herpes simplex virus. Most cases are associated with herpes simplex virus type I (the cause of cold sores or fever blisters), although rare cases can be caused by herpes simplex virus type II (genital herpes). It is poorly understood why some people who are infected with herpes simplex virus develop herpes simplex encephalitis while others do not. Changes (mutations) in genes such as TLR3 and TRAF3 have been observed suggesting there may be a genetic component in some cases. Treatment consists of antiviral therapy.[1][2]
Last updated: 8/26/2015

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

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Medical Terms Other Names
Learn More:
HPO ID
80%-99% of people have these symptoms
CSF lymphocytic pleiocytosis 0200149
EEG abnormality 0002353
30%-79% of people have these symptoms
Fatigue
Tired
Tiredness
[ more ]
0012378
Fever 0001945
Headache
Headaches
0002315
Hyponatremia
Low blood sodium levels
0002902
Increased CSF protein 0002922
Leukocytosis
Elevated white blood count
High white blood count
Increased blood leukocyte number
[ more ]
0001974
Loss of consciousness
Passing out
0007185
Nausea and vomiting 0002017
Neurological speech impairment
Speech disorder
Speech impairment
Speech impediment
[ more ]
0002167
Neutrophilia
Increased blood neutrophil counts
0011897
Nuchal rigidity 0031179
Respiratory failure requiring assisted ventilation 0004887
5%-29% of people have these symptoms
Alcoholism 0030955
Cerebral edema
Swelling of brain
0002181
Chills 0025143
Coma 0001259
Elevated C-reactive protein level 0011227
Excessive daytime somnolence
More than typical sleepiness during day
0001262
Focal aware seizure 0002349
Focal impaired awareness seizure 0002384
Functional motor deficit 0004302
Hyperreflexia
Increased reflexes
0001347
Hypoglycorrhachia
Low glucose levels in cerebral spinal fluid
0011972
Immunodeficiency
Decreased immune function
0002721
Status epilepticus
Repeated seizures without recovery between them
0002133
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Last updated: 7/1/2020

FDA-Approved Treatments

The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.


Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.

Conditions with similar signs and symptoms from Orphanet
Differential diagnosis includes: other viral causes of encephalitis, (varicella zoster virus, enteroviruses etc); bacterial infections, including ricketsial disease, mycoplasma pneumonia, chlamydophila infections; autoimmune diseases, such as paraneoplastic limbic encephalitis, acute disseminated encephalomyelitis, Rasmussen subacute encephalitis; and other causes including space occupying lesion and non-infectious encephalopathy.
Visit the Orphanet disease page for more information.

Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.

Clinical Research Resources

  • ClinicalTrials.gov lists trials that are related to Herpes simplex encephalitis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

    Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease


These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

In-Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Herpes simplex encephalitis. Click on the link to view a sample search on this topic.

Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.


  1. Anderson WE. Herpes Simplex Encephalitis. Medscape Reference. April 2014; http://emedicine.medscape.com/article/1165183-overview.
  2. Klein RS. Herpes simplex virus type 1 encephalitis. UpToDate. August 2014; https://www.uptodate.com/contents/herpes-simplex-virus-type-1-encephalitis.