National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Larsen syndrome

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My 25-year-old son has Larsen syndrome. He currently weighs 6kg and his height is 70cm. Is his low height and weight due to Larsen syndrome?

The following information may help to address your question:


What are the signs and symptoms of Larsen syndrome?

The signs and symptoms of Larsen syndrome vary from person to person, but may include the following:[1][2][3]
  • Joint dislocation (especially of the hips, knees, and elbows)
  • Hypermobile joints
  • Characteristic face such as flat, rectangular face, depressed nasal bridge, prominent forehead, and widely spaced eyes (hypertelorism)
  • Long fingers with broad ends (spatula-like) especially of the thumbs, and short nails
  • Short arms
  • Cleft palate
  • Clubfoot
  • Curved spine (scoliosis and kyphosis)  that may compress the spinal cord and lead to weakness of the arms and/or legs, and other problems
  • Short stature
  • Breathing problems in infancy (due to soft cartilage in the airway)
  • Heart (cardiovascular) anomalies
  • Hearing loss
  • Small extra bones in the wrists and ankles that may be seen in the X-rays.
Last updated: 3/8/2018

What is the final adult height for people with Larsen syndrome?

People with Larsen syndrome typically have a final adult height of less than 152 centimeters or 59.8 inches.[4]
Last updated: 4/1/2014

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

Warm regards,
GARD Information Specialist

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  1. Wiedemann HR, Kunze J, Grosse FR. In: Mosby-Wolfe. Clinical Syndromes. Italy: 1997; 3th:
  2. Larsen syndrome. Genetics Home Reference. September, 2011; http://ghr.nlm.nih.gov/condition/larsen-syndrome.
  3. Robertson S. FLNB-Related Disorders. GeneReviews. October 17, 2013; http://www.ncbi.nlm.nih.gov/books/NBK2534/.
  4. Cassandra L. Kniffin. Larsen syndrome; LRS. OMIM. February 26, 2007; http://omim.org/clinicalSynopsis/150250?search=larsen&highlight=larsen. Accessed 4/1/2014.