National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Scleromyxedema

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My husband was 43 years old when he died from complications associated with scleromyxedema. We have 2 daughters and one son. Is it hereditary, and should they be tested for the disease?

The following information may help to address your question:


What causes scleromyxedema?

The underlying cause of scleromyxedema remains unknown.[1][2] In a few cases, it has been reported in association with cancers of the bone marrow such as myeloma, lymphoma and leukemia.[3]
Last updated: 3/13/2017

Is scleromyxedema inherited?

To our knowledge, there is currently no evidence that scleromyxedema is inherited. We are not aware of any reports in the medical literature describing scleromyxedema affecting more than one member of a family.
Last updated: 3/13/2017

Is genetic testing available for scleromyxedema?

No. Genetic testing is not available because the cause of scleromyxedema is not known.
Last updated: 4/18/2014

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

Warm regards,
GARD Information Specialist

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  1. Koronowska SK, Osmola-Mankowska A, Jakubowicz O, Zaba R. Scleromyxedema: a rare disorder and its treatment difficulties. Postepy Dermatol Alergol. April, 2013; 30(2):122-126.
  2. Rongioletti F. Scleromyxedema. UpToDate. Waltham, MA: UpToDate; 2015;
  3. Eugene Tan. Lichen myxoedematosus. DermNet NZ. 2008; http://dermnetnz.org/immune/scleromyxoedema.html.