National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Muckle-Wells syndrome

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Is Muckle-Wells Syndrome life threatening?
Muckle-Wells syndrome can have severe consequences as a result of long-term high levels of inflammation in the body.[1] In some patients, this leads to secondary or AA amyloidosis, an abnormal accumulation of the protein amyloid in the tissues and organs. This can become life-threatening due to a permanent build-up of amyloid in the kidneys, liver, spleen, and elsewhere.[1][2] The most common clinical presentation is kidney failure.[2] 
Last updated: 10/17/2011

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  1. Muckle-Wells Syndrome (MWS) . NOMID Alliance. http://www.nomidalliance.net/subpage.html. Accessed 10/17/2011.
  2. Secondary AA. Amyloidosis Foundation. http://www.amyloidosis.org/TreatmentInformation/secondaryAA.html. Accessed 10/17/2011.