Muckle-Wells syndrome

Learning disabilities, including expressive language disorders, are generally not reported as a feature of Muckle-Wells syndrome.

The gene responsible for Muckle-Wells syndrome, called NLRP3, is also responsible for related conditions including the less severe familial cold autoinflammatory syndrome and the more severe neonatal onset multisystem inflammatory disease (also called NOMID, or CINCA). These conditions are collectively called cryopyrin associated periodic syndromes (CAPS). Some authors have suggested that the signs and symptoms of people with NLRP3 gene mutations may overlap more than previously thought.^[1] The features that typically distinguish NOMID from the other conditions include chronic aseptic meningitis, which can result in severe developmental delay and disability.^[2] While people diagnosed with Muckle-Wells syndrome generally do not have chronic aseptic meningitis, mild features of NOMID have been reported in some people with Muckle-Wells syndrome.^[2]