An ankle-brachial index is a tool that can be used by many medical providers, including physicians, nurse practitioners/physician extenders, and nurses. One study showed in general practice setting that nurses were the highest utilizer of this diagnostic tool.[6][7]

This tool plays a valuable clinical role across many specialties, including:

• Medicine
• Primary care
• Vascular surgery
• Plastic surgery
• Trauma
• Orthopedic surgery
• Podiatry
• Emergency medicine
• Wound care

• Rest patient. Different guidelines suggest the patient should have a specific rest period before the assessment of ABI, ranging from 10 to 30 minutes.
• Avoid nicotine. Studies show that smoking selectively affects the ankle but not the brachial systolic pressure resulting in artificially elevated values.[4]
• Supine position. There is a documented increase in the ABI value by approximately 0.3 with sitting instead of the supine position.[8]
• Quiet space: Avoid underestimating systolic pressure due to difficulty with the audibility of systolic sounds.
• Supported limbs: Reduces motion, and the patient is more likely to be relaxed.
• Cover wounds: Reduce the risk of contaminating wound or equipment.

Cuff Application Sites

Arm: Mid-arm

Ankle: Above level of malleoli

For the manual method, apply stethoscope or doppler to sites of brachial, dorsalis pedis, and posterior arteries as described in the anatomy section.

Inflate cuff 20 to 30mm Hg above the last heard sound then slowly release pressure. The first heart sound is the pressure that should be recorded as the systolic pressure at that site.

Order: The AHA suggests performing the order of measurements as follows: First arm, same side ankle (both PT and DP), opposite leg and opposite arm.[4]

 If there is a 10m Hg difference in the arm, it is recommended to recheck the initial arm to address the “white coat effect” of blood pressure measurement.[9]

Calculation: The calculation is the ratio of the systolic pressure at the ankle over the systolic pressure at the arm. The appropriate value to use for the systolic ankle pressure has been a subject of debate. The most commonly used is the highest value of the ankle values.[10] One study looked at alternative methods including averaging values, dorsalis pedis only, posterior tibial only, and lowest value.  This study suggests all have prognostic value. The difference is the “threshold” for abnormal values and varies slightly (0.87 to 0.95).

Studies demonstrate value variability based on experience as well as the same patient different days and between offices/ specialties.[11] One study suggests repeatability is the best using high ankle/highest arm.[12] A suggested minimal significant difference between recorded ABI values is 0.15. Also, consider training. About one-third of providers who reported performing procedure demonstrated “correct” use per study.[7]

Values

• Normal: 0.9 to 1.4 [13]
• High: greater than 1.4, typically indicative of vessel stiffening
• Low:  less than 0.9 - narrowing of vessels
• Non-measurable: Unable to occlude blood vessel at 300mmHg of pressure application.

Minimal variations in ABI value occur with race, sex, age, and height, but overall predictability of PAD similar amongst groups.[13][14]

Special considerations for the pediatric population: In early infancy, ABI values average lower values than adults (58% below 0.9); however, ABI reaches normal values after 12 months.[15] Studies support use in the pediatric population to reduce radiation exposure of more invasive tests with good reliability.[16]

In general, the variation in measurements is less in young, healthy individuals.

Clinical Uses

Peripheral Arterial Disease (PAD)

The AHA suggests considering evaluation in patients of age over 50 and smoker, patients with diabetes, or over age 70  for peripheral arterial disease.[4] In one screening study involving asymptomatic 50 years old patients; 20% were identified to have PAD.[17] One study suggested that providers in the general medical community use the information to initiate cardiovascular risk reduction interventions.[7] Peripheral arterial disease results suggest that ABI is better at detecting greater than 50% stenosis and proximal lesions better than distal lesions.[18] Both low and high ABI values have an independent association of cardiovascular events.[14] Also, abnormal ABI correlates with the risk of chronic kidney disease.[19]

Several studies have used ABI for prediction of additional risk due to low invasiveness and relative ease of performance to the test:

• Studies show correlations of ABI less than 0.9 with increased risk for PVD, MI, renal disease, HTN.[20]
• Lower ABI also associated with high carotid plaque score.[21]
• There is a higher risk of recurrent stroke (HR 1.7) and vascular evens/ death (2.22).[22]

Ulcer Management

Traditionally ABI was thought to have a role in wound healing. One study evaluating heel wounds showed ABI was not reliable for heel pressure sores.[23] Another study suggested that ABI is predictive of further need for amputation in diabetic wounds, but not in wound healing itself.[24] An ABI under 0.5 increased the likelihood of amputation by 40%.[25]

ABI is useful in the evaluation of critical limb ischemia. One management protocol suggests that in the setting of critical limb ischemia, a normal or inability to perform ABI warrants more invasive evaluation. If there is abnormality to the ABI, promote surveillance if no tissue loss/gangrene and revascularization if the case of tissue loss or gangrene.[26]

After revascularization, there is a correlation between change in ABI value and ulcer wound healing (ABI delta greater than or equal to 0.23, HR 1.87 for wound healing).[27]

ForPpost-surgical Healing

Surgical healing prediction:

• ABI has been reported useful in total knee arthroplasty procedures. Lower ABI (less than 0.7) shows an increased chance of total knee arthroplasty failure.[28]
• Patients with lower ABI more likely to have delayed healing when undergoing heart surgery.[29]
• Evaluation of flap placement in foot/ankle trauma 0.9 to 1.2.[30]

Trauma

ABI has a role for initial evaluation and management of blunt trauma and knee dislocations as a method of assessing for vascular injury.[31][32][33][34] The widely used criteria is an ABI less than 0.9 as an abnormal value for knee dislocations. For low values (less than 0.9), further evaluation is warranted, including methods such as ultrasound, MRI, CT, and angiography. For values greater than 0.9, serial monitoring is the recommendation (48 to 72 hours).[35][36] ABI can provide correlation with physical exam monitoring, exhibiting good reliability (sensitivity ABI 49.5  % vs. ABI + exam 100%); however, if the two do not agree, further evaluation may be warranted.[37][38]

Claudication

Occult PAD in 20% of patients referred to orthopedic surgery for leg pain in patients over 50 years old.[17]

One study found that the value of the ABI was not necessarily predictive of current functional status, but there is prognostic value with a greater likelihood to have decreased in functional status over time with lower baseline values.[20][39]

Also, there are conditions associated with claudication unrelated to arterial disease. These conditions include functional popliteal syndrome,[40] and exercise-induced leg pain.[41] In these individuals, muscle hypertrophy of the soft tissues can lead to vessel occlusion, which is important to note/consider when evaluating a patient for exertional compartment syndrome as these patients would not be expected to improve after fasciotomy.

The use of ABI for patient care requires knowledgeable individuals who are trained to do so. Training is necessary for the full team of providers from the physicians, physician extenders, and nurses. One randomized control trial evaluated the optimal way to teach the ABI procedure to medical students. The study compared didactic versus experiential learning. Results showed that experiential learning significantly improved the ability to perform the test correctly accurately.[42] (Level 2 evidence - small randomized control trial.)

Performance, application, and interpretation of ABI require an interprofessional team approach, including physicians, specialists, and specialty-trained nurses, all collaborating across disciplines to achieve optimal patient results. [Level V]

Performing ABI assessment does take time; estimated 15 minutes. As such, it will often fall on the duty of the nurse to perform the evaluation to assist in clinical flow.

Wound Care Providers

Guidelines exist for monitoring wound care application[7][43]:

• Avoid compression dressing with ABI 0.5 and refer to the specialist/supervising provider
• Values 0.5 to 0.8 apply low compression only
• Greater than 0.8 may apply high compression

The key to monitoring is establishing protocols for ABI.

An appropriate protocol for nursing monitoring should address the following three questions: Which values should I use? What periods to perform the test? When should I notify someone?  Routine trauma monitoring for injuries such as knee dislocations has been suggested at intervals of every 2 hours. This approach should consist of clinical assessment and determination if ABI is necessary at the same time with every clinical evaluation.  Other options include ABI at specific periods (i.e., a clinical exam every 2 hours and ABI every 4 hours) or only if there is a change in the clinical exam.