The cerebellum is a vital component in the human brain as it plays a role in motor movement regulation and balance control. The cerebellum coordinates gait and maintains posture, controls muscle tone and voluntary muscle activity but is unable to initiate muscle contraction. Damage to this area in humans results in a loss in the ability to control fine movements, maintain posture, and motor learning.[1][2][3]

The cerebellum, which is the largest part of the hindbrain, is located in the posterior cranial fossa, behind the fourth ventricle, the pons, and the medulla oblongata. Tentorium cerebelli, an extension of the dura matter, separates the cerebellum from the cerebrum. It is composed of two hemispheres joined by the vermis and is sub-divided into three lobes – anterior, posterior, and flocculonodular, which are separated by two transverse fissures. The V-shaped primary fissure separates the anterior and posterior lobe, while the posterolateral fissure separates the posterior and flocculonodular lobes. A deep horizontal fissure found within the posterior lobe separates the superior and inferior surfaces of the cerebellum. The cerebellum is neuron-rich, containing 80% of the brain’s neurons organized in a dense cellular layer.[1][4]

The cerebellar cortex is a sheet-like structure, made of a single sheet less than 1mm thick, and accordion-like folds fused at the midline (Essen 2018). Each fold is composed of an inner white matter core that is covered by gray matter. The gray matter of the cortex divides into three layers: an external - the molecular layer; a middle - the Purkinje cell layer; and an internal - the granular layer. The molecular layer contains two types of neurons: the outer stellate cell and the inner basket cell.[4][5]

The Purkinje layer consists of Purkinje cells, which are large Golgi type I neurons. Their dendrites reach the molecular layer and have multiple branches. The axons are long, pass through the granular layer, enter the white matter, acquire a myelin sheath, and terminate in the intracerebellar nuclei. Their collateral branches make synaptic contacts with the basket and stellate cells of the granular layer. Climbing and mossy fibers provide the primary input to the cerebellar cortex. Mossy fibers use glutamate, while the climbing fibers use aspartate as their main excitatory neurotransmitter to provide excitatory signals to the Purkinje cells. The climbing fibers are named so because they travel in the cortex like vine branches on a tree. They represent the terminal ending of the olivocerebellar tracts. The mossy fibers are the terminal branches of all other cerebellar afferent tracts. Each mossy fiber may stimulate thousands of Purkinje cells via multiple branching.[4][6]

Function: The cortex of the vermis coordinates the movements of the trunk, including the neck, shoulders, thorax, abdomen, and hips. Control of the distal extremity muscles is by the intermediate zone of the cerebellar hemispheres, located adjacent to the vermis. The remaining lateral area of each cerebellar hemisphere provides the planning of sequential movements of the entire body along with involvement in the conscious assessment of movement errors.[3][7]

Nuclei: The cerebellum consists of an outer layer of highly convoluted gray matter (cerebellar cortex) surrounding a highly branched body of white matter known as the arbor vitae (Latin for “tree of life”), which in turn surrounds the 3 pairs of deep cerebellar nuclei embedded in the central cerebellar white matter (corpus medullaris). From medial to lateral, the deep nuclei are the fastigial, interposed (consisting of globose and emboliform nuclei), and dentate nuclei, which is the largest nuclei.[1] Fibers from the dentate, emboliform, and globose nuclei leave the cerebellum through the superior cerebellar peduncle. Fibers from the fastigial nucleus exit through the inferior cerebellar peduncle.[1][8]

The cerebellum develops from the hindbrain vesicle that gives rise to the posterior part of the alar plates of the metencephalon. The cerebellar hemisphere and vermis form by the 12th week. Accordion-like folds gradually start developing from about the fourth month. Neurons of cerebellar cortex form by the neuroblast derived from the matrix cells in the ventricular zone. Other neuroblasts from the ventricular surface differentiate into cerebellar nuclei, which axons grow towards the mesencephalon (midbrain) and create the superior cerebellar peduncle. Later, projections of the axons of the corticopontine and the pontocerebellar fibers will develop the middle cerebellar peduncle and connect the cerebral cortex with the cerebellum. The inferior cerebellar peduncle will form mainly by the growth of sensory axons from the spinal cord, the olivary and vestibular nuclei.[9]

The cerebellum receives vascular supply from three main arteries that originate from the vertebrobasilar anterior system: the superior cerebellar artery (SCA), the anterior inferior cerebellar artery (AICA), and the posterior inferior cerebellar artery (PICA).

The SCA branching varies based on embryology; it can branch either from the junction point of the basilar artery and posterior cerebral artery and pass below the oculomotor nerve, or directly from the posterior cerebral artery and pass above the oculomotor nerve. In the majority of subjects, the SCA encircles the brainstem below the oculomotor nerve and above the trigeminal nerve. The SCA splits into two branches: medial and lateral. The medial branch of the SCA further splits into two branches; one supplies the mesencephalon and inferior and superior colliculi while the second supplies the superior portion of the vermis and the superomedial cerebellar cortex. The lateral branch of the SCA supplies the superolateral cerebellar cortex. Blood vessels have deeper penetration in the vermis that makes it more echogenic on fetal ultrasound.[10][11]

The AICA branches off the basilar trunk in almost all subjects. It passes the abducens nerve and meets with the facial and vestibulocochlear nerves at the cerebellopontine angle. It then divides into two branches: one supplies the anterior inferior cerebellum while the other supplies the flocculus, choroid plexus, and the middle cerebellar peduncle.[10][11]

PICA is the largest vertebral artery branch. It passes between the cerebellum and the medulla and supplies the cerebellar nuclei, inferior surface of the vermis, and the undersurface area of the cerebellar hemisphere. Medulla oblongata and the choroid plexus of the fourth ventricle are supplied by PICA, which may give rise to posterior spinal arteries in some anatomical variations. The cerebellum is drained by veins that empty into the great cerebral vein or adjacent venous sinuses.[10]

The cerebellum attaches to the brainstem by three groups of nerve fibers called the superior, middle, and inferior cerebellar peduncles, through which efferent and afferent fibers pass to connect with the rest of the nervous system. The following tables summarize how the cerebellum connects with the cerebrum (Table 1), the brainstem (Table 2), and the spinal cord (Table 3).[1][3]

• Table 1: Connection of cerebellum with the cerebrum
• Table 2: Connection of cerebellum with the brainstem
• Table 3: Connection of cerebellum with the spinal cord