History

Like all workups, chest pain evaluation starts with taking a complete history. Start by getting a good understanding of their complaint.

• Onset: In addition to when the pain started, ask what the patient was doing when the pain started. Was the pain brought on by exertion or were they at rest?
• Location: Can the patient localize the pain with one finger or is it diffuse?
• Duration: How long did the pain last?
• Character: Let the patient describe the pain in his or her own words.
• Aggravation/alleviating factors: It is very important to find out what makes the pain worse. Is there an exertional component, is it associated with eating or breathing? Is there a positional component? Don't forget to ask about new workout routines, sports, and lifting. Ask what medications they have tried.
• Radiation: This may clue you into visceral pain.
• Timing: How many times do they experience this pain? For how long does it let up?

Ask about other symptoms such as:

• Shortness of breath
• Nausea and vomiting
• Fever
• Diaphoresis
• Cough
• Dyspepsia
• Edema
• Calf pain or swelling
• Recent illness

Evaluate for any of the following risk factors:

• ACS risks: prior myocardial infarction(MI), family history of cardiac disease, smoking, hypertension (HTN), hyperlipidemia (HLD), and diabetes
• Pulmonary embolism (PE) risks: prior deep venous thrombosis (DVT) or PE, hormone use (including oral birth control), recent surgery, cancer, or periods of non-ambulation
• Recent gastrointestinal (GI) procedures like scopes
• Drug abuse (cocaine and methamphetamines)

Carefully review the patient’s medical history for cardiac history, coagulopathies, and kidney disease. Ask about family history, especially cardiac, and ask about social histories like drug use and tobacco use.

Once you have thoroughly ruled out life-threatening causes, move on to other possibilities. Pneumonia should be considered in patients with a productive cough and/or recent upper respiratory infection (URI). Gastroesophageal reflux disease (GERD) is a common cause of chest pain so ask about any reflux symptoms. New exercise routines or recent trauma may help support a musculoskeletal cause. [2]

Physical

The physical exam should include:

• Full set of vitals including blood pressure (BP) measurements in both arms
• General appearance, noting diaphoresis and distress
• Skin exam for the presence of lesions (shingles)
• Neck exam for jugular venous distension (JVD), especially with inspiration (Kussmaul sign)
• Chest, palpate for reproducible pain and crepitus
• Heart exam
• Lung exam
• Abdominal exam
• Extremities for unilateral swelling, calf pain, edema, and symmetric, equal pulses

Many facilities have protocols in place to evaluate for chest pain, but at a minimum, the provider should order the following:

• Electrocardiogram (ECG) preferably in the first 10min of arrival, (consider serial ECGs)     
• Chest x-ray
• Complete blood count (CBC), basic metabolic panel (BMP), troponin level (consider serial troponin levels 4hr apart), lipase
• Computed tomography pulmonary angiography (CTPA) if you are considering PE or ventilation-perfusion (VQ) scan if CTPA is contraindicated
• Bedside ultrasound (US) if you are considering pericardial tamponade

Acute coronary syndrome (ACS)

A complete discussion of the management of ACS is beyond the scope of this paper however initial steps should be performed in patients with a diagnosis of ACS. Place patient on a cardiac monitor, establish intravascular access (IV) access, give 162 mg to 325 mg chewable aspirin, clopidogrel, or ticagrelor (unless bypass surgery is imminent), control pain and consider oxygen (O2) therapy. Nitroglycerin has shown a mortality benefit, aim for 10% mean arterial pressure (MAP) reduction in normotensive patients and 30% MAP reduction in hypertensive patients; avoid in hypotensive patients and those with inferior ST elevation. Patient with ST elevation on ECG patients should receive immediate reperfusion therapy either pharmacologic (thrombolytics) or transfer to the catheterization laboratory for percutaneous coronary intervention (PCI). PCI is preferred and should be initiated within 90 minutes onsite or 120 minutes if transferred to outside facility. If PCI is not possible thrombolytics should be initiated within 30 min. Patients with non-ST elevation myocardial infarction (NSTEMI) and unstable angina should be admitted for cardiology consult and work up. Patients with stable angina may be appropriate for outpatient work up. In elderly patients and those with comorbidities, patients should be admitted for observation and further cardiac work up. [3][4]

Pulmonary embolism (PE)

CT pulmonary angiogram (CTPA) is the best confirmatory test, a VQ scan can also be used, but this test is not as accurate in patients with chronic lung disease. Patients who are hemodynamically unstable should be started on thrombolytics; stable patients should be started on anticoagulants. [5][6]

Pneumothorax (PTX)

Pneumothorax should be decompressed with a chest tube. [7][8]

Pericardial tamponade

Bedside ultrasound is useful to establish a diagnosis. A fluid bolus may be used as a temporizing measure. Needle pericardiotomy or pericardial window to relieve pressure inside the pericardial sack.[9]

Aortic dissection

Often immediate surgery is required, consult cardiothoracic surgery early. CT angiography is the best test to evaluate for dissection. Place two large-boar IVs and quickly lower patient’s blood pressure to systolic between 100 mmHg to 130 mmHg. Start with beta-blocker therapy to prevent reflux tachycardia. [10][11][12]

Esophageal perforation

A left pleural effusion on chest x-ray may suggest esophageal rupture. Contrast esophagram is the best confirmatory test. This is a medical emergency, and immediate surgical consult is warranted. [11]

Gastrointestinal reflux disease

The patient can be given viscus lidocaine mixed with Maalox (known as a GI cocktail). While this is therapeutic it is not diagnostic. ACS can present with dyspepsia and may respond to GI cocktail, it is therefor improtant to rule out ACS before assigning GERD as a final diagnosis. Long-term treatment of GERD is best accomplished with proton pump inhibitor (PPI) or H2 blocker therapy.[13]

• Acute coronary syndrome

• Aortic dissection

• Embolism

• Gastroesophageal reflux

• Muscle or skeletal pain

• Oesophageal rupture

• Pericarditis

• Pneumonia shingles

• Pneumothorax

• Pulmonary embolism

Aortic dissection can cause a stroke. Do not forget to consider this in your workup. Younger patients and those without risk factors can still have an MI. People with diabetes and the elderly may have nerve damage which may make it difficult for them to interpret pain. They may have more atypical presentations of disease like acute coronary syndrome (ACS).

Chest pain is a common symptom encountered in clinical practice by the nurse practitioner, primary provider, internist, emergency department physcian and surgeon. In most cases, a thorough medical history will provide a clue to the diagnosis. The key is to not miss a life threatening disorder like an acute MI or an aortic dissection. When the cause of chest pain remains unknown, it is recommended that the patient be referred to the specialist for care. The outcomes for patients with chest pain depend on the cause.