Corns are primarily diagnosed on clinical presentation. It is helpful to look at other lesions on an individual's skin to see their body response to physical trauma. It is also easier to diagnose corns by inspection and palpation because of their rough hyperkeratotic texture. History should also include an account of physical activities.[4][5][6]

Corns usually present as flesh-colored dry, hard, rough papules with a whitish center (called the core). They are located over a bony prominence. They are painful on walking and standing but are asymptomatic to touch. As the overgrowth/thickening of keratin builds up, corns can grow and cause severe pain.

There are two main variants of corn:

• Hard corn ('heloma durum') – The most common type, usually located over the lateral and dorsal aspect of the fifth toe as well as on the dorsal aspect of the interphalangeal joints of the lesser toes.
• Soft corn or interdigital corn ('heloma molle') – a painful hyperkeratotic lesion, mostly seen in the interdigital web spaces, especially the fourth space. This location often leads to maceration of the corn, with sometimes, the occurrence of a bacterial or fungal infection.[7]

Some authors add to these two variants a third one, called seed corn, which manifests as multiple nonpainful keratotic plugs within plantar calluses in non-pressure-bearing areas of the soles. 

Corns sometimes are difficult to distinguish from plantar warts. In corns, the plantar skin lines may be observed within the lesions, as opposed to plantar warts. Furthermore, if the physician exerts a digital pressure perpendicularly to plantar corn, this latter will come into contact with the bony prominence, and the patient will feel pain. This maneuver is generally nonpainful in the case of warts. Finally, the absence of capillary dotting called "Auspitz's sign" after paring hard corns distinguishes them from plantar warts.

Dermoscopy may help make the diagnosis showing areas of hyperkeratosis without vascular or hemorrhagic structures that are mainly seen in warts.

Radiographs of the feet may help to show bony prominences. 

Pressure studies of the feet can highlight areas of excessive plantar pressure associated with plantar corns.

Other tests, like fasting glucose level and rheumatoid factor, may be done to find the etiology of foot deformity in some patients.

The treatment aims to reduce the pain and discomfort resulting from corns.[8][9]

• The treating provider should do gentle paring of the lesion, without drawing blood, utilizing scalpels. Removing the central plug, under local anesthesia, if necessary, reduces the pressure on underlying dermal nerves, thus alleviating the pain. Patients should be advised to trim the previously treated lesions weekly, using an emery board or pumice stone, after immersing the feet in warm water for twenty minutes.
• Topical keratolytic medications, including salicylic acid 12.6% to 40% as a pad or a solution, may be applied to the corns. Urea 20% to 50%, silver nitrate, and hydrocolloid dressings can also be used in this indication. These techniques are more effective for a few lesions of interest. Topical keratolytic agents may also facilitate lesion paring by softening the corns.
• Ablative laser therapy may also be used to treat corns instead of paring them with a scalpel. The carbon dioxide laser has been reported to be efficient by some authors. The 2,940 nm erbium-doped yttrium aluminum garnet laser has been used to treat corns with minimal thermal tissue damage. However, recurrence of lesions may be observed in some patients, especially if the trigger factors are maintained.
• Any mechanical trouble and/or deformity should be managed with appropriate conservative treatment. This involves proper footwear and soft cushions (silicon sheet, sheepskin), which reduce friction and improve comfort. 

Management begins with prevention. Patients should avoid ill-fitting shoes and mechanical trauma to the affected area.

Surgical

This is directed toward the removal of the underlying cause for corns like bony prominences. Usually, it is indicated in case of failure of other conservative treatment modalities.

The differential diagnosis of a corn includes:

• Plantar wart
• Poroma
• Warty dyskeratoma
• Calcinosis cutis
• Gout and pseudogout
• Hypertrophic lichen planus
• Interdigital neuroma
• Lichen simplex chronicus
• Palmoplantar keratoderma
• Keratosis punctata of palmar creases
• Porokeratosis plantaris discreta
• Porokeratosis palmoplantar et disseminata

Although corns and calluses are a chronic, recurrent issue, most of them gradually go away when the repeated friction or pressure causes them to be eliminated. Nevertheless, if corns do not go away or if they started to cause severe pain, then the patient should be checked by a dermatologist or podiatrist.

• Ulceration
• Tenia pedis
• Septic arthritis
• Osteomyelitis

The following specialties are involved directly or indirectly in the treatment plan for cases of corn:

• Dermatology
• Neurology
• Orthopedic surgery
• Endocrinology
• Podiatry

Patients with peripheral neuropathies should try to avoid the application of plasters that contain salicylic acid because these plasters might cause sloughing of normal skin if placed in a wrong way. Calluses and corns are not caused by viruses and are not contagious. Patients should be instructed to trim their nails to avoid any pressure or repeated trauma, which might lead to the development of corns.

One of the frequent pitfalls seen in clinical practice by some dermatologists is using liquid nitrogen (cryotherapy) for treating cases of corns. This, unfortunately, can lead to aggravation of the problem, and it can add more to the patient's suffering since liquid nitrogen damages normal skin surrounding the corn and does not help in healing the lesion.

Despite treatment, corns are recurrent.[10]

The management of corns is interprofessional. Patients may be treated by the nurse practitioner, dermatologist, primary care physician, or podiatrist. The key in all cases is to eliminate the continuous pressure on the foot. The treating provider should refer the patient to an orthopedic surgeon to evaluate for underlying bony abnormalities in lesions that are recalcitrant to treatment or recurrent. Foot care nurses are often involved in the diagnosis and treatment of corns. They should educate the patient as to proper foot care and follow up to ensure resolution. Pharmacists often recommend over the counter products and should also educate the patients.