Patients present commonly with cardinal symptoms like nausea, vomiting, early satiety, postprandial fullness, upper abdominal pain, bloating and weight loss. The gastroparesis cardinal symptom index (GCSI) is a validated clinical instrument that be can be used to assess symptoms in patients suffering from gastroparesis. This instrument has three subscales: (fullness/early satiety, nausea/vomiting, and bloating) and rates of symptom intensities from zero (none) to five (very severe) and the total is used for severity of the disease. The GCSI is used to assess response to therapy and not primarily as a diagnostic tool. In addition to gastric symptoms, the slow and unpredictable gastric emptying can cause wide fluctuations in blood sugar levels especially so in diabetic patients. In addition, this may cause weight loss, fatigue, calorie deficit, gastric bezoar formation.

Initial assessment of upper gastrointestinal tract by esophagogastroduodenoscopy or barium radiography is done to rule out a mechanical obstruction. The most common test used in clinical practice is the gastric scintigraphic emptying of solids. A study result of retention of solids at 4 hours is considered to be diagnostic of gastroparesis. Other alternative methods to assess gastric emptying include motility testing by a wireless capsule and 13 C breath testing using octanoate or spirulina integrated into a solid meal. Drugs that affect the gastric emptying should be held at least 48 hours prior to the study. Furthermore, patients with diabetes should have plasma blood glucose less than 275 mg/dl to eliminate acute impairment of gastric emptying from hyperglycemia.[8][9][10][11]

Diet and Lifestyle Changes

The initial goal of the management of gastroparesis is the restoration of fluid and electrolyte balance. Also, nutritional status and blood sugar levels should be optimized. Dietary modifications include switching to small frequent meals, low-fat diet. Drinks such as carbonated and alcoholic beverages and foods rich in insoluble fiber should be avoided entirely. In addition, quitting smoking has also been reported to be helpful. Oral intake is encouraged, and if the patient does not tolerate solid foods, then a liquid diet could be attempted. In case of intolerance to oral diet, enteral feeding by post-pyloric feeding tube can be used. Parenteral nutrition is not encouraged and remains the last alternative if everything else fails.[12][13][14]

Pharmacological and Surgical Methods

The use of prokinetics like metoclopramide, erythromycin and anti-emetics can help relieve symptoms. Metoclopramide is the first-line agent; it is a dopamine D2 receptor antagonist that increases contractility, resting tone of GI tract and thereby promotes gastric emptying. It is recommended to use the lowest possible dose for the shortest duration of time given its extrapyramidal side effects unless benefits outweigh risks. Domperidone is similar to metoclopramide but with fewer central side effects and can be used when there are adverse effects with the use of metoclopramide. It is not FDA approved for use in the USA.  Domperidone can be prescribed by obtaining expanded access to investigational new drugs from the FDA. Erythromycin can be used for a short course to promote gastric emptying, but prolonged use is associated with tachyphylaxis and should be used sparingly. Other antiemetics used are prochlorperazine, promethazine, ondansetron, and tricyclic agents such as nortriptyline in the case of refractory emesis.

Intrapyloric botulinum injections have been demonstrated to improve symptoms in patients that are refractory to the above medical therapies. The effects of the botulinum injections last for about 3 to 6 months. Lack of randomized controlled trials to support the use of botulinum is the main limitation. A gastric electrical stimulator (GES) used in refractory patients as an alternative modality, it delivers high frequency and low energy stimulation to the stomach, thus enhancing gastric motility. Studies have also shown improvement in symptoms and gastric emptying from the use of GES. Surgical approaches include venting gastrostomy, feeding jejunostomy, pyloroplasty, and partial gastrectomy are performed when medical therapy fails for symptom relief. A new emerging, less invasive endoscopic technique gastric peroral endoscopic myotomy (G-POEM) is being evaluated to relieve the symptoms of gastroparesis. The initial studies are encouraging, will need further studies to evaluate efficacy and safety.

Gastroparesis mimics several other conditions such as like anorexia nervosa, bulimia, and rumination syndrome. Therefore, these conditions need to be excluded prior to making a diagnosis of gastroparesis. Other conditions such as cyclical vomiting syndrome and chronic cannabinoid use may also have a similar clinical pattern as gastroparesis.

Post-infectious gastroparesis is usually self-limiting and patients might recover within the next 12 months of initial symptoms.

Diabetic gastroparesis is usually slowly progressive and can become severe and even lethal in some cases

• Dehydration
• Malnutrition. 
• Indigestion
• Hypoglycemia
• Hyperglycemia
• Decreased quality of life. 

Medications, such as opioids for pain relief, antidepressants, hypertension medications, and allergy medications, can lead to slow gastric emptying, feeling of fullness and thus cause similar symptoms. For people who already have gastroparesis, these medications should be avoided as it can worsen the condition.

Gastroparesis is a clinical condition associated with obstructive gastric symptoms in the absence of mechanical obstruction that is observed in a variety of clinical conditions. There is no definitive treatment for this condition currently. Unfortunately, management options are limited and mostly focused on symptom relief. Several new treatment alternatives are emerging to manage this condition but need further studies to evaluate clinical benefit.

Gastric stasis is associated with high morbidity and because of the many causes, the condition is best managed by an interprofessional team that includes a gastroenterologist, endocrinologist, surgeon, internist, pharmacist, dietitian and the primary care provider. The pharmacist has to ensure that the patient is not on any medications that cause gastric paralysis. All reversible causes have to be sought and treated. Patients with diabetes need to manage their blood sugars well. Unfortunately, despite optimal treatment, gastric stasis is often a chronic problem that leads to poor quality of life. Some patients need continuous TPN and others need comprehensive changes in diet and lifestyle.

To date, the use of prokinetic drugs has not been effective. Placement of pacemakers in the stomach does work in a few people but there are no long term studies.

Surgical approaches include venting gastrostomy, feeding jejunostomy, pyloroplasty, and partial gastrectomy are performed when medical therapy fails for symptom relief. [15][16]