Iliotibial band syndrome is a clinical diagnosis and rarely requires further studies and imaging. The physician must be vigilant about mechanical symptoms, changes in activity level, mileage of long-distance activity, and condition of training shoes. The patient often presents with lateral knee pain localized to the area between the Gerdy tubercle and the lateral epicondyle. The history is commonly consistent with a recent change in prolonged aerobic activities and rarely in the setting of an acute injury. The pain initially will occur at the completion of the activity but may be present at the beginning of the activity and even at rest with later disease progression. Furthermore, the pain is often worse with running on a cambered surface, and also hills or longer strides may increase symptoms as deeper knee flexion at foot strike and leads to more time in the "impingement zone."[3]

The first step in physical examination of the knee. Coronal and sagittal plane knee misalignments such as genu varum, genu valgum, recurvatum, and procurvatum are worth noting as this can increase tension on the ITB. Knee effusion or ligamentous laxities are not commonly part of the presentation with isolated ITBS. Palpation of the distal ITB can be painful, and the physician may feel crepitus with range of motion. Special tests for ITBS include the Noble and Ober tests. To perform the Noble test, the physician first palpates the lateral femoral epicondyle and then extends the knee from 90 degrees of flexion to 0 degrees of extension. Reproducible pain at 30 of flexion is a positive test. The Ober test involves placing the patient in the lateral recumbent position with the knees flexed to 90. The physician stands behind the patient and abducts and extends the affected hip while supporting the knee. A positive test is indicated by restriction and pain to the lateral knee while the physician adducts the hip in this extended position.[9]

Radiographic imaging of the knee is useful for ruling out other pathology that could be causing lateral knee pain such as osteoarthritis, fracture, or patella malalignment. ITBS in the absence of other pathology will appear normal on plain radiograph of the knee. If the diagnosis is still unclear after the history and physical, an MRI of the knee may confirm the diagnosis if it demonstrates hyperintensities at the lateral epicondyle with a thickened distal ITB. Additionally, ultrasound is a low cost and low-risk modality that will may abnormal distal ITB thickening.[3]

The first line treatment for the vast majority of patients with ITBS is nonoperative management. The patient should be advised to refrain from the inciting activity until the pain has resolved. Intermittent cryotherapy can help with acute flares. A gradual return to activity can commence as soon as the patient is pain-free with activity and palpation. Physical therapy focused on stretching of the ITB and abduction strengthening can be very effective at lengthening the ITB and reducing tension. Furthermore, manual therapy such myofascial release with a foam roller has been used to break up adhesions and is an integral part of the rehabilitation process.[3] The physical therapist should also focus on teaching proper ergonomics and posture while performing inciting activities.

Non-steroidal anti-inflammatories can help with diminishing the inflammation. Likewise, corticosteroid injections can be therapeutic, as well as diagnostic for ITBS by providing immediate and prolonged pain relief.[10] Shoe modification, foot orthosis, and sport specific technique training can help prevent ITBS from returning in some cases. Most patients will have complete symptom relief and able to return to activity within 6 to 8 weeks with nonoperative management alone.

The recommended progression back to activity starts with a week of running on alternating days on a flat surface. The following weeks are focused on fast-paced running daily and avoid downhill running. After 3 to 4 weeks, the patient can gradually increase the distance and frequency. Introducing hills and cambered surfaces should only take place if there is no pain or symptoms on a flat surface.   If the patient relapses, then they will need to start their activity progression over again and may require a period of rest beforehand.

Surgical intervention is only for refractory cases despite nonoperative management for more than 6 months. There are several surgical options including percutaneous or open ITB release, ITB lengthening with a Z-plasty, open ITB bursectomy, and arthroscopic ITB debridement.  Furthermore, there are several different techniques described for the open ITB release including resecting a triangular portion of the distal posterior ITB band, resecting the 2 cm x 4 cm portion overlying the lateral femoral epicondyle and also making a V-shaped incision in the ITB.[11][12][9] All of the different techniques have demonstrated success, but there are limited comparative studies to demonstrate superiority.  ITB bursectomy is the indicated option with the symptomatology of ITBS but no enhancement of the ITB on MRI. The procedure consists of excising the underlying ITB bursa but leaving the ITB completely intact. One study demonstrated that the majority of patients who undergo open bursectomy are overall completely or mostly satisfied with the results.[13] Minimal invasive techniques have been described to resect the lateral synovial recess that connects the ITB to the lateral femur and innervated synovial fat.  Michels et al. described this arthroscopic technique and showed a 97% good to excellent result with all patients returned to full activity.[14]

The following lists the most common causes of lateral knee pain:

• Stress fracture of the lateral tibial plateau
• Lateral meniscus tear
• Lateral compartment of the knee osteoarthritis
• Lateral collateral ligament strain
• Biceps femoris tendinopathy
• Radiation from hip pathology
• Patellofemoral syndrome
• Popliteal tendinopathy

Roughly 50 to 90% of patient will improve with 4 to 8 weeks of non-operative modalities. Likewise, all surgical modalities have reported good to excellent results.[9][12] ITBS typically follows a fluctuating course and may relapse at any point in the treatment progression or return to activity.

Disease progression is the most common complication of ITBS. As the disease progresses, the patient will experience pain throughout the activities and even at rest. Furthermore, because of its attachments to the lateral patella, the progression of the disease may lead to the patellofemoral syndrome.

Patient education and adherence to the treatment plan is the key to treating this disorder. Running at faster paces and on a flat ground have been shown to limit the time in the so-called "impingement zone” between the lateral femoral epicondyle and ITB. Furthermore, patients must change their shoes regularly to prevent uneven wear of the soles.[3] Patients may also benefit from a personal trainer or physical therapist to improve their sport-specific biomechanics. It is crucial that the patient is aware that the ITBS can sometimes relapse after returning to activities, and they should restart the nonoperative treatment progression. 

Successful treatment of ITBS is only possible through an interprofessional approach. Patients with ITBS often present initially to their primary care physician/nurse practitioner and nonoperative treatment can be started at that time before seeing an orthopedic surgeon. Physical therapy is imperative to strengthening the abductors, loosening the ITB tension, and teaching proper biomechanics during the activity. The sport specific trainers must also be knowledgable on how to prevent or minimize activities that are at high risk for developing this syndrome.  Open communication with the patient, physical therapist, and treating physician is imperative to limit progression or relapse of the disease.

TO summarize, ITBS requires an interprofessional team approach, including physicians, specialists, physical therapists, specialty-trained nurses, and occasionally pharmacists, all collaborating across disciplines to achieve optimal patient results. [Level V]