The inferior gluteal nerve innervates the gluteus maximus muscle. This muscle is primarily responsible for hip, torso extension, and returning from a squat position. The gluteus maximus muscle has a broad base origin from the posterior surface of the iliac crest down to the lateral border of the coccyx with fascial insertion onto the sacral multifidus and gluteus medius and inserts itself into the gluteal tuberosity of the femur and portions of the iliotibial fascia. Bartlett and colleagues examined the gluteus maximus muscle during different active movements and found that sprinting far superseded climbing, walking, and running. They compared this muscular pattern to that of apes and found that among different insertional patterns, humans had more gluteus maximus activation during sprinting, suggesting an evolutionary adaptation.[7]

Some studies have examined variations in the course of the inferior gluteal nerve. Tillman found in 112 subjects 17 had the inferior gluteal nerve pass through the piriformis similar to the variations seen with the sciatic nerve; they observed it that this variation was more common in men.[8] In a rare case from Sumalatha et al., the inferior gluteal nerve was absent, and a division of the common peroneal nerve innervated the gluteus maximus. Although most anatomy textbooks will show the inferior gluteal nerve passing below the piriformis in approximately 0.2% to 4.4% of the adult population, the inferior gluteal nerve will pass superiorly to the piriformis.[9]

Total Hip Arthroplasty (THA)

Posterolateral approach

One of the most common surgical approaches preferred by total joint replacement surgeons is the posterolateral approach.  This dissection does not utilize a true inter-nervous plane. The intermuscular interval involves blunt dissection of the gluteus maximus fibers proximally and sharp incision of the fascia lata distally. The deep dissection involves meticulous dissection of the short external rotators and the hip joint capsule. Care is necessary to protect these structures as they are later repaired back to the proximal femur via trans-osseous tunnels.[10]

Peripheral nerve injury in THA

Multiple studies have reported the incidence rates and overall risk of peripheral nerve injuries during the most common THA approaches. The incidence rates reported vary widely in the literature.  Reports dating back to the 1980s and 1990s cited up to an 8% incidence rate in THA patients.[11]  More contemporary studies report a 0.6% to 3.7% risk of nerve injury in THA patients, with the incidence rate at least doubled in the revision setting.[12] The latter has much documentation in the literature dating back to the early 1970s.[13][14]

Inferior gluteal nerve considerations

While most literature reports focus injury to the sciatic, femoral, obturator, superior gluteal, and lateral femoral cutaneous nerves, much less attention is given to the inferior gluteal nerve.  Also, the exact clinical outcome "definition" varies significantly from study to study, and with the majority of nerve injuries, fortunately, being mild in nature (i.e., mild neuropraxia), the postoperative clinical examination likely underestimates the true incidence of neurologic injuries following THA; this is particularly true in the case of the inferior gluteal nerve.

Multiple cadaveric studies have documented the anatomy and course of the inferior gluteal nerve concerning its anatomic susceptibility during the posterolateral approach to the hip.  Apaydin et al. used 36 cadavers to develop a triangular landmark for the inferior gluteal nerve; this region included: posterior inferior iliac spine, ischial tuberosity, and greater trochanter.[15]

Other technical considerations

While many authors support the utilization of minimal invasive THA techniques, the potential benefits of these procedures can only truly achieve clinical fruition with superior knowledge of nerve anatomy, as trading the benefits of superior visualization during these procedures can potentially be offset by an increased risk of iatrogenic neurovascular injuries.

Techniques to reduce the likelihood of nerve compromise are achievable; one way is through a more minimally invasive total hip arthroplasty, where the surgeon does not dissect the gluteus maximus tendon and removes less tissue significantly reducing nerve compromise.[16] That said, superior knowledge of the course of the nerve requires mastery as

Marcy et al. describe a different approach to the hip. They do not split the gluteus maximus, but only retracted the muscle backward with little damage to the nerve. This technique, however, has its disadvantages, high mobilization of the muscles, and labor-intensive.[17] With this in consideration, the more preferred approach is to split the gluteus maximus muscles. The incision must be 5mm or less from the tip of the greater trochanter and extend approximately 10 cm along the iliotibial tract; this route will protect the inferior gluteal nerve.

The sciatic nerve is typically the focus in piriformis syndrome, but any structure passing through the infra-piriform foramen can be compromised, including the inferior gluteal nerve. inferior gluteal nerve entrapment will have primary signs of gluteus maximus atrophy.[18] Seddon and Sunderland classification to peripheral nerve compromise is a valuable tool to use when testing a neurological injury. Seddon and Sunderland create five main classes of nerve compromise; neurapraxia, axonotmesis I-III, and neurotmesis. During neurapraxia, focal demyelination occurs; this is the least severe state and usually has the best chance of full recovery. Axonotmesis is a more progressive stage of nerve injury and will involve the axon. Progression from axonotmesis grade I to III will involve the surrounding endoneurium and perineurium, this stage can heal, but is less likely. Neurotmesis is the most severe stage; this stage typically involves complete transection and is typically the stage post-surgical compromise; most of these conditions do not fully heal without surgical correction.[19] The preferred treatment for these issues is an end-to-end repair of the severed nerve. Kretschmer et al. reported a good recovery in 70% post-surgical repair of iatrogenic nerve damage.[20]

Perisacral surgical techniques offer a different type of difficulty. During perisacral surgery to remove tumors, the surgeon must have clear landmarks developed, or they risk cutting the superior and or inferior gluteal artery. The sacrospinous and sacrotuberous ligament are landmarks that the surgeon must identify because these two ligaments lie over the superior and inferior gluteal artery. Traditional surgical techniques removed more gluteus tissue, which made identification of the arteries easier, but also compromised functional recovery because of tissue loss.[21]