Renal lymphoma is commonly seen as a part of the spectrum of multi-systemic; however, it may seldom be seen as a primary disease. It usually presents in middle-aged persons although half of the cases may be clinically silent. Presenting symptoms include flank pain, weight loss, fever, night sweats, palpable abdominal mass, hematuria, and deranged renal function usually seen as elevated serum creatinine.

Primary renal lymphoma is an infiltrative tumor that grows without disruption of structure or function. However, the most common presentation of primary renal lymphoma is acute renal failure, flank pain, and mass. The cause for renal failure is somewhat ambiguous, but several theories have been postulated including lymphomatous infiltration of the parenchyma, hypercalcemia due to vitamin D overproduction by the lymphomatous mass or ureteral, and vascular or tubular compression by the lesion.

Renal Function Studies

Laboratory studies to assess renal function include blood urea nitrogen (BUN) and creatinine. Although clinical evidence of renal involvement with lymphoma is only seen in 2% to 14 %of patients, an elevated serum creatinine is reported in 26% to 56%. An elevated BUN or creatinine level may indicate bilateral ureteral obstruction subsequent to massive retroperitoneal lymph nodes or as a adverse effect of nephrotoxic chemotherapeutic agents.[8][9][10]

Renal Biopsy

The diagnosis of primary renal lymphoma requires biopsy in most cases as imaging findings are nonspecific. Although fine-needle aspiration is a useful technique, core tissue biopsy with flow cytometry and immunohistochemical staining is recommended as it has a higher diagnostic accuracy according to several studies.

With regard to secondary renal lymphoma (SRL), renal biopsy is usually not required in the presence of disseminated disease. However, it is reported that patients with lymphoma have a higher incidence of renal cell carcinoma (RCC) than the general population. Differentiating SRL presenting as a solitary mass (typically hypovascular) from clear cell RCC (mostly hypervascular) on imaging may be straightforward. Nonetheless, other histologic subtypes of RCC, like papillary and chromophobe RCCs, can also appear hypovascular on imaging, making it harder to differentiate from SRL. In such cases, a renal biopsy may be validated.

Imaging

There are several patterns of lymphomatous involvement of kidneys; the most common on imaging is multiple parenchymal nodular masses of variable size, typically 1 to 4.5 cm in diameter. This presentation is seen in approximately 50 to 60% of cases. The lesions are usually bilateral, but unilateral renal presentation can also be seen. The second most common pattern of involvement constitutes a contiguous extension to the kidneys or perinephric space from large retroperitoneal nodal masses (seen in 25% to 30% of cases).

Renal lymphoma presenting as a solitary mass is encountered in 10% to 25% of patients. On non-enhanced CT scan lymphomatous mass is slightly more hyperattenuating than the surrounding normal renal parenchyma. At contrast-enhanced CT, the mass is hypovascular and characteristically demonstrates minimal enhancement. This feature is invaluable in differentiating renal lymphoma from RCC, which mostly manifests moderate to avid enhancement in the arterial phase. Isolated perinephric lymphoma is rarely seen (less than 10% of cases). Contrast-enhanced CT scans are important for demonstrating a ring of homogeneous perinephric tissue which encases the normal parenchyma, with contrast-enhanced causing any significant renal dysfunction. Diffuse renal enlargement without distortion of the reniform shape of the kidneys or formation of any discrete masses presents in 6% to 19% of cases. Nephromegaly is almost always bilateral. If both kidneys are extensively infiltrated, acute renal failure. Contrast-enhanced CT demonstrates heterogeneous enhancement of the kidneys, loss of the normal corticomedullary differential enhancement, encasement and deformation of the pevicalyceal system, and infiltration of the renal sinus fat. Alternatively, the renal parenchyma is replaced by poorly defined low-attenuation lesions. The collecting system is encased and stretched instead of being displaced. The sonographic picture of infiltrative renal lymphoma is globular enlargement of the kidneys with heterogeneous echotexture and effacement of renal sinus.

Nuclear Imaging

Gallium-67 citrate has been used for diagnosing and staging lymphoma. This radioisotope concentrates in lymphoma. and is taken up by lymphomatous tissue in the kidneys. It also is concentrated in the inflammatory masses of the kidney. The degree of sensitivity increases in case of high grade lymphoma.18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scanning has been commonly used for staging and follow-up after treatment. The use of another agent, technetium-99m (Tc)-labeled antibody (LL2), has been advocated in imaging and staging lymphomas, especially in cases of low-grade lymphoma.

Differentiating renal lymphoma from other renal masses is crucial as well as challenging, especially in cases of unilateral lesions that mimic renal carcinomas both radiologically as well as pathologically. The standard management of a renal mass is radial or partial nephrectomy. However, a patient with renal lymphoma is treated with systemic chemotherapy.

Surgery or systemic chemotherapy, with or without radiotherapy, is a widely-used treatment for primary renal lymphoma. The prognosis of patients affected by primary renal lymphoma is grave, despite the absence of disseminated disease. For bilateral renal lymphoma, systemic chemotherapy using a CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen is the treatment of choice; this preserves the organ function, but the subsequent prognosis is poor because although chemotherapy usually improves the renal function. The few cases reported in the literature show increased mortality because of rapid relapse or infections occurring from neutropenia. Alternatively, bilateral nephrectomy invariably leads to the permanent need for hemodialysis. Overall survival rate and long-term disease-free interval are relatively better when surgery and chemotherapy are combined.

• Abscess

• Acute pyelonephritis

• Angiomyolipoma

• Bladder cancer

• Chronic pyelonephritis

• Non-Hodgkin lymphoma

• Renal adenoma

• Renal cyst

• Renal infarction

• Wilms disease

Lymphoma of the kidney may be primary or secondary, but in both cases making a diagnosis is not easy. The disorder is best managed by an interprofessional team that includes the pathologist, radiologist, urologist, oncologist, radiation specialist and a team of specialty nurses. To differentiate lymphoma from other renal cancers usually requires a biopsy. Once diagnosed, the treatment is chemotherapy plus radiation. The prognosis of these patients depend on whether the lymphoma is primary or secondary. With advances in treatment, most patients have improved survival but complications of therapy often can be life-threatening.[11][12]